ID   ACUK_ARTGP              Reviewed;         715 AA.
AC   E4UP58;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Transcription activator of gluconeogenesis MGYG_02011;
GN   ORFNames=MGYG_02011;
OS   Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS   gypseum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX   NCBI_TaxID=535722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4604 / CBS 118893;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; DS989823; EFQ99000.1; -; Genomic_DNA.
DR   RefSeq; XP_003174483.1; XM_003174435.1.
DR   AlphaFoldDB; E4UP58; -.
DR   SMR; E4UP58; -.
DR   STRING; 63402.XP_003174483.1; -.
DR   PRIDE; E4UP58; -.
DR   EnsemblFungi; EFQ99000; EFQ99000; MGYG_02011.
DR   GeneID; 10029760; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; E4UP58; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000002669; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..715
FT                   /note="Transcription activator of gluconeogenesis
FT                   MGYG_02011"
FT                   /id="PRO_0000406429"
FT   DNA_BIND        66..94
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  77133 MW;  C2E0BA2C95009A5E CRC64;
     MSPHQTTGQE SDNMAVNGEN APASSQYIQT NNDEMADMVA AEKKAAAAKA AKDPSRPKRK
     KAKRACYACQ RGHLTCGDER PCQRCIKRGF QDACHDGVRK KAKYLHDAPN EVLMAGVGAT
     LYNQRNAAQN NVNGSNTSPG VPQQMTSPNF YSTQQSPDYN SFPQNKNELH DSTVGPENYA
     SQSPVSPTYQ IGQGMPNPVL SPSLPQSASE TPSTANAAPG QFNSAFFDPS DPALFNFDLA
     SMNFGNHYGA LEFGMLGHMA TGVGDTPPSD SGAQRGSIGQ NGSGTFGLAG SNFAESPSNQ
     TPYLFNESGM NDWTQTAPVN RRSIYGSNAN MVAGNMSDKP HAFAIESAPA NFASPASNES
     PMMTTNSATF EDTTNSGAFS SRPNASVSQQ RQQPVVSTPQ LKQQNLNLGG RRRHKNASSI
     YDSVKDPYSY TSGFHSLTAF IQRRFSPQKT LRIAKALASI RPSFIATTKT LNRDDLIFME
     KCFQRTLWEY EDFINACGTP TIVCRRTGEI AAVGKEFSIL TGWRKEVLLG KEPNHNVNTG
     GSSGLVTDST SRGSYTPRPY SSDVYNSSTA ATPRTQPVFL AELLDDDSVI EFYEDFAKLA
     FGDSRGSVMT TCKLLKYKTK ADSDILAGSN GEADAGQNGE ASSSEANELN GSNANGATTN
     GRGLRRWGKG EIAGEAGMNQ LGFRDGKVEC SYCWTVKRDV FDIPMLIVMN FLPCI