ID   ACUK_ARTOC              Reviewed;         739 AA.
AC   C5FP02;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Transcription activator of gluconeogenesis MCYG_04674;
GN   ORFNames=MCYG_04674;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; DS995704; EEQ31855.1; -; Genomic_DNA.
DR   RefSeq; XP_002846937.1; XM_002846891.1.
DR   AlphaFoldDB; C5FP02; -.
DR   SMR; C5FP02; -.
DR   STRING; 63405.XP_002846937.1; -.
DR   EnsemblFungi; EEQ31855; EEQ31855; MCYG_04674.
DR   GeneID; 9230052; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..739
FT                   /note="Transcription activator of gluconeogenesis
FT                   MCYG_04674"
FT                   /id="PRO_0000406440"
FT   DNA_BIND        65..93
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..574
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..666
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   739 AA;  79871 MW;  AEE2209C1A83FFBE CRC64;
     MSPHQTTGQE SDNMAVNGEN AQASSQYIQL NSEETTDTVA AEKKAAAAKA KDPSRPKRKK
     AKRACYACQR GHLTCGDERP CQRCIKRGFQ DACHDGVRKK AKYLHDAPNE ALMAGVGASL
     YNQRNTTQNS INGANAPSSA SQQITSPNFY NAQQSPDYNG YSQTKAELQD STIGPENFAS
     QSPVSPTYQM GQPMPNQGLS PSLPQSASET PSTANGAPSQ FNSAFFDPSD PALFNFDLAS
     MNFGNHYGAL EFGMLGHMAT GVGDTPPSDN GAQRGSIGQN SSGTFGLAGS NFAESPSNQG
     PYLFGDSGMN DWTQSAPVNR RNMYGSNANM VAGNMSDKPH AFAIESAPAN FASPASNESP
     MMTTSSATFE DAANATAFNS RQNTSLPQQQ QQQRQQPVVS TPQLKQQNLN IGSRRRHKNA
     SSIYDSVKDP YSYTSGFHSL TAFIQRRFSP QKTLRIAKAL ASIRPSFIAT TKTLNRDDLI
     FMEKCFQRTL WEYEDFINAC GTPTIVCRRT GEIAAVGKEF SILTGWRKEV LLGKEPNHNV
     NTGGSSGLLT GSTSRGSYTP RPYSSDQFNS STTATPRTQP VFLAELLDDD SVIEFYEDFA
     KLAFGDSRGS VMTTCKLLKY KTKADSGVIA SGNGEVGAAQ NNEVGSGEAN ELNSSSNGTT
     STGRGQRRWG KGEIAGEAGM NQLGFRDGKV ECSYCWTVKR DVFDIPMLIV MNGEMECMEV
     NIITSGQPNY QAFRALVKD