ACUK_ASPCL
ID ACUK_ASPCL Reviewed; 698 AA.
AC A1C602;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Transcription activator of gluconeogenesis acuK;
GN Name=acuK; ORFNames=AN7468;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC utilization. Activator of gluconeogenetic genes (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR EMBL; DS027045; EAW13823.1; -; Genomic_DNA.
DR RefSeq; XP_001275249.1; XM_001275248.1.
DR AlphaFoldDB; A1C602; -.
DR SMR; A1C602; -.
DR STRING; 5057.CADACLAP00006444; -.
DR EnsemblFungi; EAW13823; EAW13823; ACLA_068510.
DR GeneID; 4707944; -.
DR KEGG; act:ACLA_068510; -.
DR VEuPathDB; FungiDB:ACLA_068510; -.
DR eggNOG; ENOG502R1M5; Eukaryota.
DR HOGENOM; CLU_010748_1_0_1; -.
DR OMA; VMTTCKL; -.
DR OrthoDB; 681770at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..698
FT /note="Transcription activator of gluconeogenesis acuK"
FT /id="PRO_0000406430"
FT DNA_BIND 69..97
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 75805 MW; 1AEE9421BEAC6485 CRC64;
MNVEAKESSV APAGDHGGAV QDPADVRDRL ELLKNKANGE TNGATPNGTK STNAKDPSRP
RRKKARRACF ACQRAHLTCG DERPCQRCIK RGLQDACHDG VRKKAKYLHD APDGALMPGV
GGNFYNHPMR HNMPLSSNGA NAVNATSQQN SGASFYPTPQ SNPYNVYQES TLSQNSFPSQ
SPVSPTFNMK NTATARSNSL SSSVNQPQSN PAASGPPSQS QNPFAGPFFD PSDPALFNFD
LSSMNFENRY GALEFGMLGH MATGAGDSPS ESATQRGSIG RSGSAQFATT PITGNPGFGE
SPGNQQPFMF GNDPLLNEWP NNHPPGQGHM NVGGVYPQNS MMAGHLSKAD APHAFAIESG
PASFSSPSAT TSPHVNGGYD ENALSNAVAH KPNGLPTNGQ RPAITTPRLK HQSLQLGVKR
RHRNPSTVYE SVKEPYAYTN RFHNLTAFIQ RRFSSQKTLQ IAKALASIRP SFIATTKTLN
RDDLIFMEKC FQRTLWEYED FINACGTPTI VCRRTGEIAA VGKEFSILTG WKKDVLLGKE
PNLNVNTGGT SIPQSGTSSR GSFTPRISTL EQANPARPQP VFLAELLDDD SVVDFYEDFA
RLAFGDSRGS VMTTCKLLKY KTKEDMELAQ SDDNQRWNNH LRKGGIAGEA GMNQLGFKDG
KVECAYCWTV KRDVFDIPML IVMNYLIPSD GFKSSIPF