ID   ACUK_ASPFC              Reviewed;         683 AA.
AC   B0XVV1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Transcription activator of gluconeogenesis acuK;
GN   Name=acuK; ORFNames=AFUB_022860;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP54234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS499595; EDP54234.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; B0XVV1; -.
DR   SMR; B0XVV1; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..683
FT                   /note="Transcription activator of gluconeogenesis acuK"
FT                   /id="PRO_0000406431"
FT   DNA_BIND        65..93
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          537..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..568
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  74093 MW;  A63CD9A6D929413E CRC64;
     MKTEVNGSAP ALAGDHGGVD QDTPDAGDRT EQAKHKTNGA TENAPKSANA KDPSRPRRKK
     ARRACFACQR AHLTCGDERP CQRCIKRGLQ DACHDGVRKK AKYLHDAPDG ALMPGVGGNF
     YNNAMRNNMP LSRNGTTTVN TTTQQNSGSN YYPTPQSNSY NVYQDTPLTQ NSFPSQSPVS
     PTFNMKTTPT ARSNSLSSSV NQQPPSTTVS GATQSQNPFA GPFFDPSDPA LFNFDLSSMN
     FENRYGALEF GMLGHMATGA GDSPTDSATQ RGSIGRSGST QYSTTPLTGA PGFGESPGNQ
     QPFLFGNDPL LNEWPNSQAP NQGHLNVSGV YPQGGMMHMA KSDAPHAFAI ESGPASFSSP
     SATTSPHINS GHDESSLSNA AVNKSTGLTA NGQRPAITTP SLKHQSLQFG VKRRQRNPST
     VYESVKEPYA YTNRFHNLTA FIQRRFSPQK TLQIAKALAS IRPSFIATTK TLNRDDLIFM
     EKCFQRTLWE YEDFINACGT PTIVCRRTGE IAAVGKEFSI LTGWKKDVLL GKEPNLNVNT
     GGSSAPGSGN TSRGSFTPRS STLETATPGR PQPVFLAELL DDDSVVEFYE DFARLAFGDS
     RGSVMTTCKL LKYKTKEDME LAQSDDNQRW NNHLRKGGIA GEAGMNQLGF KDGKVECAYC
     WTVKRDVFDI PMLIVMNVFL PCI