ID   DDA1_DANRE              Reviewed;         104 AA.
AC   Q7T2A3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DET1- and DDB1-associated protein 1 {ECO:0000250|UniProtKB:Q9BW61};
GN   Name=dda1 {ECO:0000250|UniProtKB:Q9BW61}; ORFNames=zgc:64154;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a component of numerous distinct DCX (DDB1-CUL4-
CC       X-box) E3 ubiquitin-protein ligase complexes which mediate the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. In the DCX complexes, acts as a scaffolding subunit required
CC       to stabilize the complex. {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- SUBUNIT: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-
CC       protein ligase complexes which consist of a core of DDB1, cullin-4
CC       (CUL4A or CUL4B), DDA1 and RBX1. {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- SIMILARITY: Belongs to the DDA1 family. {ECO:0000305}.
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DR   EMBL; BC054628; AAH54628.1; -; mRNA.
DR   RefSeq; NP_998292.1; NM_213127.1.
DR   RefSeq; XP_005155757.1; XM_005155700.3.
DR   AlphaFoldDB; Q7T2A3; -.
DR   SMR; Q7T2A3; -.
DR   STRING; 7955.ENSDARP00000112315; -.
DR   PaxDb; Q7T2A3; -.
DR   PRIDE; Q7T2A3; -.
DR   Ensembl; ENSDART00000123601; ENSDARP00000112315; ENSDARG00000076074.
DR   Ensembl; ENSDART00000140960; ENSDARP00000119610; ENSDARG00000076074.
DR   GeneID; 796589; -.
DR   KEGG; dre:796589; -.
DR   CTD; 79016; -.
DR   ZFIN; ZDB-GENE-040426-2137; dda1.
DR   eggNOG; KOG4816; Eukaryota.
DR   GeneTree; ENSGT00390000007029; -.
DR   HOGENOM; CLU_144562_1_0_1; -.
DR   InParanoid; Q7T2A3; -.
DR   OMA; DLPCHNE; -.
DR   OrthoDB; 1521756at2759; -.
DR   PhylomeDB; Q7T2A3; -.
DR   TreeFam; TF323534; -.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q7T2A3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000076074; Expressed in somite and 29 other tissues.
DR   ExpressionAtlas; Q7T2A3; baseline.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR   InterPro; IPR033575; DDA1.
DR   InterPro; IPR018276; DDA1_N.
DR   PANTHER; PTHR31879; PTHR31879; 1.
DR   Pfam; PF10172; DDA1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..104
FT                   /note="DET1- and DDB1-associated protein 1"
FT                   /id="PRO_0000310274"
FT   REGION          67..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   104 AA;  11982 MW;  8057AFD3BCCE936F CRC64;
     MDKADFLKGL PVYNKTNFSR FHADSVCKAS NRRPSVYLPT REYPSEQIIV TEKTNILLRY
     LHQQWDKKNA AKKREQEQAE GEGGSPAPPR KIARTDSQEM NEDS