ID   DDA1_XENLA              Reviewed;         101 AA.
AC   Q5U550;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=DET1- and DDB1-associated protein 1 {ECO:0000250|UniProtKB:Q9BW61};
GN   Name=dda1 {ECO:0000250|UniProtKB:Q9BW61};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a component of numerous distinct DCX (DDB1-CUL4-
CC       X-box) E3 ubiquitin-protein ligase complexes which mediate the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. In the DCX complexes, acts as a scaffolding subunit required
CC       to stabilize the complex. {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- SUBUNIT: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-
CC       protein ligase complexes which consist of a core of DDB1, cullin-4
CC       (CUL4A or CUL4B), DDA1 and RBX1. {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- SIMILARITY: Belongs to the DDA1 family. {ECO:0000305}.
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DR   EMBL; BC084834; AAH84834.1; -; mRNA.
DR   RefSeq; NP_001088502.1; NM_001095033.1.
DR   AlphaFoldDB; Q5U550; -.
DR   SMR; Q5U550; -.
DR   MaxQB; Q5U550; -.
DR   DNASU; 495370; -.
DR   GeneID; 495370; -.
DR   KEGG; xla:495370; -.
DR   CTD; 79016; -.
DR   Xenbase; XB-GENE-6078316; dda1.L.
DR   OrthoDB; 1521756at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 495370; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR033575; DDA1.
DR   InterPro; IPR018276; DDA1_N.
DR   PANTHER; PTHR31879; PTHR31879; 1.
DR   Pfam; PF10172; DDA1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..101
FT                   /note="DET1- and DDB1-associated protein 1"
FT                   /id="PRO_0000310275"
FT   REGION          67..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   101 AA;  11743 MW;  8C56C35B9CECF30F CRC64;
     MADFLKGLPV YNESNFSRFH ADSVCKASNR RPSVYLPTRE YPSDQIIVTE KTNILLRYLH
     QQWDKKNAAK KRDQDQLEIG ETSAPPRKIA RTDSQEMNED T