ID   DDA1_XENTR              Reviewed;         101 AA.
AC   Q5BL73;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DET1- and DDB1-associated protein 1 {ECO:0000250|UniProtKB:Q9BW61};
GN   Name=dda1 {ECO:0000250|UniProtKB:Q9BW61}; ORFNames=TNeu111h01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a component of numerous distinct DCX (DDB1-CUL4-
CC       X-box) E3 ubiquitin-protein ligase complexes which mediate the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. In the DCX complexes, acts as a scaffolding subunit required
CC       to stabilize the complex. {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- SUBUNIT: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-
CC       protein ligase complexes which consist of a core of DDB1, cullin-4
CC       (CUL4A or CUL4B), DDA1 and RBX1. {ECO:0000250|UniProtKB:Q9BW61}.
CC   -!- SIMILARITY: Belongs to the DDA1 family. {ECO:0000305}.
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DR   EMBL; CR760393; CAJ82685.1; -; mRNA.
DR   EMBL; BC090578; AAH90578.1; -; mRNA.
DR   RefSeq; NP_001017216.1; NM_001017216.2.
DR   AlphaFoldDB; Q5BL73; -.
DR   SMR; Q5BL73; -.
DR   STRING; 8364.ENSXETP00000029871; -.
DR   PaxDb; Q5BL73; -.
DR   DNASU; 549970; -.
DR   GeneID; 549970; -.
DR   KEGG; xtr:549970; -.
DR   CTD; 79016; -.
DR   Xenbase; XB-GENE-973045; dda1.
DR   eggNOG; KOG4816; Eukaryota.
DR   HOGENOM; CLU_144562_1_0_1; -.
DR   InParanoid; Q5BL73; -.
DR   OMA; DLPCHNE; -.
DR   OrthoDB; 1521756at2759; -.
DR   PhylomeDB; Q5BL73; -.
DR   TreeFam; TF323534; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q5BL73; baseline.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
DR   InterPro; IPR033575; DDA1.
DR   InterPro; IPR018276; DDA1_N.
DR   PANTHER; PTHR31879; PTHR31879; 1.
DR   Pfam; PF10172; DDA1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..101
FT                   /note="DET1- and DDB1-associated protein 1"
FT                   /id="PRO_0000310276"
FT   REGION          67..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   101 AA;  11716 MW;  8C56C34A6CECF30F CRC64;
     MADFLKGLPV YNESNFSRFH ADSVCKASNR RPSVYLPTRE YPSDQIIVTE KTNILLRYLH
     QQWDKKNAAK KRDQDQLEIG ETSAPPRKIA RTDSQEMSED T