ID   DDAC_ENTAG              Reviewed;         329 AA.
AC   E2JA28;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Dapdiamide synthesis protein DdaC {ECO:0000305};
DE            EC=1.-.-.- {ECO:0000305};
GN   Name=ddaC {ECO:0000303|PubMed:20945916};
OS   Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea; Pantoea agglomerans group.
OX   NCBI_TaxID=549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, COFACTOR, AND PATHWAY.
RC   STRAIN=CU0119;
RX   PubMed=20945916; DOI=10.1021/ja1072367;
RA   Hollenhorst M.A., Bumpus S.B., Matthews M.L., Bollinger J.M. Jr.,
RA   Kelleher N.L., Walsh C.T.;
RT   "The nonribosomal peptide synthetase enzyme DdaD tethers N(beta)-
RT   fumaramoyl-l-2,3-diaminopropionate for Fe(II)/alpha-ketoglutarate-dependent
RT   epoxidation by DdaC during dapdiamide antibiotic biosynthesis.";
RL   J. Am. Chem. Soc. 132:15773-15781(2010).
CC   -!- FUNCTION: Involved in dapdiamide antibiotics biosynthesis. Catalyzes
CC       the alpha-ketoglutarate-dependent epoxidation of the covalently bound
CC       N-beta-fumaramoyl-DAP-S-DdaD to generate N-beta-epoxysuccinamoyl-DAP in
CC       thioester linkage to DdaD. {ECO:0000269|PubMed:20945916}.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000269|PubMed:20945916};
CC   -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000269|PubMed:20945916}.
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DR   EMBL; HQ130277; ADN39482.1; -; Genomic_DNA.
DR   RefSeq; WP_033781251.1; NZ_JPOT02000004.1.
DR   AlphaFoldDB; E2JA28; -.
DR   SMR; E2JA28; -.
DR   BioCyc; MetaCyc:MON-19479; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.130.10; -; 1.
DR   InterPro; IPR042098; TauD-like_sf.
DR   InterPro; IPR003819; TauD/TfdA-like.
DR   Pfam; PF02668; TauD; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Oxidoreductase.
FT   CHAIN           1..329
FT                   /note="Dapdiamide synthesis protein DdaC"
FT                   /id="PRO_0000434791"
SQ   SEQUENCE   329 AA;  37207 MW;  9C53DE46BAFB82DD CRC64;
     MSHSYNVRPL VSGAPHVSLV TASTSDASID EFFSHHPIDE ILSEKGALLF RGFSINEDQQ
     FSQLVSILAK EELTYQERST QRKKTAQGVY TSTEYPAAKT IANHSENAFQ QVVPGKILFY
     AHQAALKGGE TPIADNSRVL SLIDEEIVAE FRQKGIRYLR NFDGGFDLSW QEAFQTEKKR
     EVETYCVKNA IDCEWLSDSH LRTSQLRSAT RRHPLNRKEM WFNQLHLFHI TNLELPVRQA
     LLASLGHDLL PRHAVYGTGE EIPDEVVDHI RAALVKAELV FPWQTGDVLI ADNILVSHGR
     KPFEGERAVR VALIDPVYPS AEENPHAQR