ID   ACUK_ASPOR              Reviewed;         688 AA.
AC   Q2UMM2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Transcription activator of gluconeogenesis acuK;
GN   Name=acuK; ORFNames=AN7468;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; AP007154; BAE57193.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2UMM2; -.
DR   SMR; Q2UMM2; -.
DR   STRING; 510516.Q2UMM2; -.
DR   EnsemblFungi; BAE57193; BAE57193; AO090001000703.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   OMA; VMTTCKL; -.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..688
FT                   /note="Transcription activator of gluconeogenesis acuK"
FT                   /id="PRO_0000406434"
FT   DNA_BIND        68..96
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          137..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          174..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  74131 MW;  F3018BF34C026749 CRC64;
     MTVDAQDSTP APPADRRGAE LETGGVGEQS EQPKNKSNGD GNAPAETGQK PNPKDPSRPR
     RKKARRACFA CQRAHLTCGD ERPCQRCIKR GLQDACHDGV RKKAKYLHDA PDGALMPGIG
     GNFYNNTMRS NLPLSRNGAN AVNATTQPSS SPNFYPTPQS NSYSVYQENT MNQNSFTSQS
     PVSPTFTLKA NPAARNNSLS SQVNQQPPST GVSGATNPSQ NPFAGPFFDP SDPALFNFDL
     SSMNFENRYG ALEFGMLGHM ATGAGDSPSD SATQRGSMGR SGSAQFSGTP ITGAAAFGES
     PGGQQPFIFG DPLLNEWSSG QPTGQTHVNV GGVYPQSGQG SVIPGHLTKA DAPHAFAIES
     GPGSFASPNA TTSPQITTGF DDATFSSAVT AKSNGLSANG PRPTITTPSL KHQNLQVGVR
     RRQRNPSSIY ENVKEPYAYT NRFHNLTAFI QRRFSPQKTL QIAKALASIR PSFIATTKTL
     NRDDLIFMEK CFQRTLFEYE DFINACGTPT IVCRRTGEIA AVGKEFSILT GWKKDVLLGK
     EPNLNVNTGG SVPGSGTSSR SFTPRGSVAE STPGRPQPVF LAELLDDDSV VEFYEDFARL
     AFGDSRGSVM TTCKLLKYKT KEDMENQSDD NQRWNSHLRK GGIASEAGMN QLGFKDGKIE
     CAYCWTVKRD VFDIPMLIVM NASSTNLR