ID   ACUK_ASPTN              Reviewed;         691 AA.
AC   Q0CHR0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Transcription activator of gluconeogenesis acuK;
GN   Name=acuK; ORFNames=AN7468;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CH476602; EAU33318.1; -; Genomic_DNA.
DR   RefSeq; XP_001215952.1; XM_001215952.1.
DR   AlphaFoldDB; Q0CHR0; -.
DR   SMR; Q0CHR0; -.
DR   STRING; 341663.Q0CHR0; -.
DR   EnsemblFungi; EAU33318; EAU33318; ATEG_06774.
DR   GeneID; 4321941; -.
DR   VEuPathDB; FungiDB:ATEG_06774; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..691
FT                   /note="Transcription activator of gluconeogenesis acuK"
FT                   /id="PRO_0000406435"
FT   DNA_BIND        70..98
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          549..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..571
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  74530 MW;  4364B389284AD902 CRC64;
     MKVESRENQP SAASADRSGA DQESGAAERP DPSKKTDDGK PHAPAENGQK PPSNAKDPSR
     PRRKKARRAC FACQRAHLTC GDERPCQRCI KRGLQDACTD GVRKKAKYLH DAPDGALMPG
     VGGNFYSSNN NNSSMRNNLP LSRNGANAVN ANAQQNTGAN FYPTPQSTSY NVYQENPINQ
     SSFTSQSPVS PTFNLKTNPT ARTNSLSSVG QQPPTTTGVS GPNPQNPFAG ALFDPSDPAL
     FNFDLSSMNF ENRYGALEFG MLGHMATGAG DSPSDSATQR GSMGRSGSAQ FSNTPITGQP
     GFGESPGGQQ PFMFGDPLLN EWPGGQASGQ AHVNVGGVYP QSGQGSVIPG HLSKTDAPHA
     FTIESGPNFA SPSATTSPQM TSGFDDHALN NAVAKSNGMA NGQRPTISTP SLKHQSLQIG
     AKRRPRNPSS IYESVKEPYA YTNRFHNLTA CIQRRFSPQK TLQIAKALAS IRPSFIATTK
     TLNRDDLIFM EKCFQRTLWE YEDFINACGT PTIVCRRTGE IAAVGKEFSI LTGWKKDVLL
     GKEPNLNVNT GGSSLPGSGT TSRSFTPRGS VGESTAPGRP QPVFLAELLD DDSVVEFYED
     FARLAFGDSR GSVMTTCKLL KYKTKEDMEL AQSDDNQRWN NHLRKGGIAS EAGMNQLGFK
     DGKVECAYCW TVKRDVFDIP MLIVMNFLPC I