ID   DDB1_SOLLC              Reviewed;        1090 AA.
AC   Q6QNU4;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA damage-binding protein 1;
DE   AltName: Full=High pigmentation protein 1;
DE   AltName: Full=UV-damaged DNA-binding protein 1;
GN   Name=DDB1; Synonyms=hp1;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, VARIANT HP1 TYR-311, AND MUTAGENESIS
RP   OF GLU-798.
RX   PubMed=15178762; DOI=10.1073/pnas.0400935101;
RA   Liu Y., Roof S., Ye Z., Barry C., van Tuinen A., Vrebalov J., Bowler C.,
RA   Giovannoni J.;
RT   "Manipulation of light signal transduction as a means of modifying fruit
RT   nutritional quality in tomato.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9897-9902(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], VARIANT HP1 TYR-311, AND MUTANT HP1W.
RX   PubMed=14968305; DOI=10.1007/s00122-004-1584-1;
RA   Lieberman M., Segev O., Gilboa N., Lalazar A., Levin I.;
RT   "The tomato homolog of the gene encoding UV-damaged DNA binding protein 1
RT   (DDB1) underlined as the gene that causes the high pigment-1 mutant
RT   phenotype.";
RL   Theor. Appl. Genet. 108:1574-1581(2004).
CC   -!- FUNCTION: Component of light signal transduction machinery. Involved in
CC       fruit pigmentation and fruit nutritional quality. Acts as a negative
CC       regulator of fruit pigmentation. Probably acts by participating in the
CC       CDD complex, a complex probably required to regulate the activity of
CC       ubiquitin conjugating enzymes. Repression of photomorphogenesis is
CC       probably mediated by ubiquitination and subsequent degradation of
CC       photomorphogenesis-promoting factors such as HY5.
CC       {ECO:0000269|PubMed:15178762}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Probable component of the CDD complex, which probably also
CC       contains DET1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: The hp1 variant was originally discovered as a
CC       spontaneous mutant at the Campbell Soup company farms (Riverton, N.J.).
CC   -!- SIMILARITY: Belongs to the DDB1 family. {ECO:0000305}.
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DR   EMBL; AY531660; AAS21683.1; -; mRNA.
DR   EMBL; AY452480; AAR20885.1; -; mRNA.
DR   RefSeq; NP_001234275.1; NM_001247346.1.
DR   AlphaFoldDB; Q6QNU4; -.
DR   SMR; Q6QNU4; -.
DR   STRING; 4081.Solyc02g021650.2.1; -.
DR   PaxDb; Q6QNU4; -.
DR   PRIDE; Q6QNU4; -.
DR   GeneID; 778355; -.
DR   KEGG; sly:778355; -.
DR   eggNOG; KOG1897; Eukaryota.
DR   InParanoid; Q6QNU4; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; Q6QNU4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:EnsemblPlants.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phytochrome signaling pathway; Reference proteome.
FT   CHAIN           1..1090
FT                   /note="DNA damage-binding protein 1"
FT                   /id="PRO_0000079842"
FT   VARIANT         311
FT                   /note="N -> Y (in hp1; induces exaggerated light
FT                   responsiveness)"
FT                   /evidence="ECO:0000269|PubMed:14968305,
FT                   ECO:0000269|PubMed:15178762"
FT   MUTAGEN         798
FT                   /note="E->K: In hp1w; induces exaggerated light
FT                   responsiveness."
FT                   /evidence="ECO:0000269|PubMed:15178762"
SQ   SEQUENCE   1090 AA;  121733 MW;  CF44BC8C1B1F1DF9 CRC64;
     MSVWNYVVTA HKPTNVTHSC VGNFTGPQEL NLIIAKCTRI EIHLLTPQGL QPMLDVPIYG
     RIATLELFRP HGETQDLLFI ATERYKFCVL QWDTEASEVI TRAMGDVSDR IGRPTDNGQI
     GIIDPDCRLI GLHLYDGLFK VIPFDNKGQL KEAFNIRLEE LQVLDIKFLY GCPKPTIVVL
     YQDNKDARHV KTYEVSLKDK DFIEGPWAQN NLDNGASLLI PVPPPLCGVL IIGEETIVYC
     SASAFKAIPI RPSITRAYGR VDADGSRYLL GDHNGLLHLL VITHEKEKVT GLKIELLGET
     SIASTISYLD NAFVFIGSSY GDSQLVKLNL QPDTKGSYVE VLERYVNLGP IVDFCVVDLE
     RQGQGQVVTC SGAYKDGSLR IVRNGIGINE QASVELQGIK GMWSLRSATD DPYDTFLVVS
     FISETRVLAM NLEDELEETE IEGFNSQVQT LFCHDAVYNQ LVQVTSNSVR LVSSTSRDLK
     NEWFAPVGYS VNVATANATQ VLLATGGGHL VYLEIGDGVL NEVKYAKLDY DISCLDINPI
     GENPNYSNIA AVGMWTDISV RIYSLPDLNL ITKEQLGGEI IPRSVLMCSF EGISYLLCAL
     GDGHLLNFVL SMSTGELTDR KKVSLGTQPI TLRTFSSKDT THVFAASDRP TVIYSSNKKL
     LYSNVNLKEV SHMCPFNVAA FPDSLAIAKE GELTIGTIDE IQKLHIRSIP LGEHARRISH
     QEQTRTFALC SVKYTQSNAD DPEMHFVRLL DDQTFEFIST YPLDQFEYGC SILSCSFSDD
     SNVYYCIGTA YVMPEENEPT KGRILVFIVE DGKLQLIAEK ETKGAVYSLN AFNGKLLAAI
     NQKIQLYKWA SREDGGSREL QTECGHHGHI LALYVQTRGD FIVVGDLMKS ISLLIFKHEE
     GAIEERARDY NANWMSAVEI LDDDIYLGAE NNFNLFTVRK NSEGATDEER SRLEVVGEYH
     LGEFVNRFRH GSLVMRLPDS DVGQIPTVIF GTVNGVIGVI ASLPHDQYLF LEKLQTNLRK
     VIKGVGGLSH EQWRSFYNEK KTVDAKNFLD GDLIESFLDL SRNRMEEISK AMSVPVEELM
     KRVEELTRLH