ID   DDC1_ASHGO              Reviewed;         543 AA.
AC   Q755A0;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA damage checkpoint protein 1;
GN   Name=DDC1; OrderedLocusNames=AFL075W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the checkpoint clamp complex involved in the
CC       surveillance mechanism that allows the DNA repair pathways to act to
CC       restore the integrity of the DNA prior to DNA synthesis or separation
CC       of the replicated chromosomes. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the checkpoint clamp complex composed of DDC1,
CC       MEC3 and RAD17. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DDC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016819; AAS53297.1; -; Genomic_DNA.
DR   RefSeq; NP_985473.1; NM_210827.1.
DR   AlphaFoldDB; Q755A0; -.
DR   STRING; 33169.AAS53297; -.
DR   PRIDE; Q755A0; -.
DR   EnsemblFungi; AAS53297; AAS53297; AGOS_AFL075W.
DR   GeneID; 4621702; -.
DR   KEGG; ago:AGOS_AFL075W; -.
DR   eggNOG; ENOG502QT39; Eukaryota.
DR   HOGENOM; CLU_490204_0_0_1; -.
DR   InParanoid; Q755A0; -.
DR   OMA; TTLCQVR; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030295; F:protein kinase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0000725; P:recombinational repair; IEA:EnsemblFungi.
DR   InterPro; IPR026217; Ddc1.
DR   InterPro; IPR007268; Rad9/Ddc1.
DR   PANTHER; PTHR15237; PTHR15237; 1.
DR   Pfam; PF04139; Rad9; 2.
DR   PRINTS; PR02063; DNADAMAGECP1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..543
FT                   /note="DNA damage checkpoint protein 1"
FT                   /id="PRO_0000239637"
FT   REGION          512..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  60479 MW;  34E29B032E576062 CRC64;
     MSFRAVITSS EHQAVWSRLI LTLSTINQDI KFTIMSNELI LWSMNSTDTT MYQVRLKASF
     FSEFSFDPGN IVFGEEGLQV IEDLQKQQHT LYSFVINGRH LSILSRKPEY DNIKEFSLSI
     DNSTAAPEAI INRLHIRVYT ESLITKEFSP AFNPVKYDPI VIDLKYKKKF LDVYGTEESV
     NGEQADPRLL DFFRQVRKQL EEAKFNEGII DAPRPAELRS EHEINFLSMD SLIWRNAIDL
     CTNNTEELKL DLTMNKMVIT AFTKGVQNMK SSDVLKQAIS ISNSVSTEDV EHYCLFTTSG
     NPGMSKKDAD SKQAVFKLRD FRNFFSANQA WKENATVNCW FCSPGDPILF EIDRGHVKLS
     LVQITDTAGK AVGAAPDLAI HPVLVSPRKP VSPLRAACTN TNAASNALHG VQLDAANMDA
     IKTLFVQDVE IGVSAAAMAH SPANRCTDEN LRSMCSISQQ GQHSCDGSPA TNLRRVSRAG
     TTIAWGAGKD HVMCPDSDYG VAQDVNQLKR RKVGELAHAS QSPESQDYGL GPTQQYQPKG
     IFD