ID   ACUK_CHAGB              Reviewed;         660 AA.
AC   Q2GSA4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Transcription activator of gluconeogenesis CHGG_09150;
GN   ORFNames=CHGG_09150;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CH408034; EAQ85136.1; -; Genomic_DNA.
DR   RefSeq; XP_001227077.1; XM_001227076.1.
DR   AlphaFoldDB; Q2GSA4; -.
DR   SMR; Q2GSA4; -.
DR   STRING; 38033.XP_001227077.1; -.
DR   EnsemblFungi; EAQ85136; EAQ85136; CHGG_09150.
DR   GeneID; 4395861; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; Q2GSA4; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..660
FT                   /note="Transcription activator of gluconeogenesis
FT                   CHGG_09150"
FT                   /id="PRO_0000406437"
FT   DOMAIN          455..526
FT                   /note="PAS"
FT   DNA_BIND        59..87
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  72331 MW;  445EBF7A4870F0FA CRC64;
     MSDSENEYDE TDQLVKEEDE KMSDQRLTSE GADTSAEPKK KYDPKDPLRP RRKKARRACF
     ACQRAHLTCG DERPCQRCIK RNLMESCQDG VRKKAKYLHD APPEALRPVL GPNYNPNPTP
     RQNGHRHPSI QTSEASSNQG TFFSQSPATQ FPLFSAAQTP IGNLAETLPF ANQQSPTSPS
     FQTSGNPQIS GMTVPQVSSP MTNFGTLPFD PSDPNIYNFN LEGLNFGSQY GAMEFGMLGH
     MSSGAAETPP GDATMARSAS GSLGFGPGVF GNGVNQFDNV YEGNILDGFL GLDANHNGLY
     SQGNLQHGLP HAYAIAAGPT SIQSPSTDTN SPQPTPLGFE GSPTMATFST TPGSKPANQQ
     RPSTRQSNAI AKLGQQSVLG KRQRDPSFVY DTVKEPFGYV SSFHKLFILI QKRFTAAHTS
     RIAKSLASIR PSLMASTKNL TKQDLVFMEK YFQRSLLEYE EFMHQCSSPT LACRRTGEVA
     IVNKEFCALT GWTKDVLLGK EPNLNVNLGG SASANTNSKA RVGLATPRLK SLNTESGGST
     DGPRPVYLAE LLDHESVVEF YEDYSQLAFN DSRGHKTRKC RLLKYRAPDK DDGTGESSTD
     GQLPQKDPRN SILSNRVAKI DGEHGISKLE RDGKLECSYT WTIKRDVFDM PMLFVINVST