ID   ACUK_COCP7              Reviewed;         713 AA.
AC   C5PHH6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Transcription activator of gluconeogenesis CPC735_053490;
GN   ORFNames=CPC735_053490;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; ACFW01000049; EER23979.1; -; Genomic_DNA.
DR   RefSeq; XP_003066124.1; XM_003066078.1.
DR   AlphaFoldDB; C5PHH6; -.
DR   SMR; C5PHH6; -.
DR   EnsemblFungi; EER23979; EER23979; CPC735_053490.
DR   GeneID; 9691594; -.
DR   KEGG; cpw:CPC735_053490; -.
DR   VEuPathDB; FungiDB:CPC735_053490; -.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..713
FT                   /note="Transcription activator of gluconeogenesis
FT                   CPC735_053490"
FT                   /id="PRO_0000406438"
FT   DNA_BIND        77..105
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..663
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   713 AA;  76992 MW;  8B20A9C00846DDBA CRC64;
     MTANAINGPV LPTPLATPGD NNKSADTTMA DQGTRPESQP QGQNNGAKPQ NGQTKPMSAA
     NAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG IQNACHDGVR KKAKYLHDAP
     NEALMPHLQG HLYTTQANTA RNTIPLTRNG SNSKTNFYPQ QQSSFNNFYQ NKPDPTLNQP
     QLHDTGRPDT FPSQSPVSPT FNMTANPAAS GNQGLPSSLS ASNSNASGQA QNGFGSAFFD
     PSDPALFNFD LASMNFGNHY GALEFGMLGH MATGAGETPP SDGATQHGSV GRSGSGTYTA
     GSNFGESPTG QPSFLFGDPT IGGDWTSSVN TRNIYGQNMN NMSETPHAFA IESAPANFAS
     PNSIESPLLT NTTTFDDNTA PTYANRANIN SVPSQRQPVV STPQLKHLQV GKRRQRNPSA
     IYDSVKEPYS YTTGFHSLTA FIQRRFSPQN TLRIAKALAS IRPSFIATTK TLNRDDLIFM
     EKCFQRTLWE YEDFINACGT PTIVCRRTGE IAAVGKEFSI LTGWKKEVLL GKEPNLNINT
     GGSSGAMSGV TSRGSFTPRT GMDINPTGRT QPVFLAELLD DESVVEFYED FAKLAFGDSR
     GSVMTTCKLL KYKTKADMDM LSGTTSSAGG ENEHGAAGNG DVKPENGMGA SNGQSQHSLQ
     RQRKWSRGGI AGEAGMNQLG FKDGKVECSY CWTVKRDVFD IPMLIVMNFL PCI