ACUK_EMENI
ID ACUK_EMENI Reviewed; 702 AA.
AC Q5AW62; C8VBE4; Q1XD65;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Transcription activator of gluconeogenesis acuK;
DE AltName: Full=Acetate non-utilizing mutant protein K;
GN Name=acuK; ORFNames=AN7468;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=17339216; DOI=10.1534/genetics.107.070904;
RA Hynes M.J., Szewczyk E., Murray S.L., Suzuki Y., Davis M.A.,
RA Sealy-Lewis H.M.;
RT "Transcriptional control of gluconeogenesis in Aspergillus nidulans.";
RL Genetics 176:139-150(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [4]
RP FUNCTION.
RX PubMed=3622; DOI=10.1099/00221287-92-2-263;
RA Armitt S., McCullough W., Roberts C.F.;
RT "Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans.";
RL J. Gen. Microbiol. 92:263-282(1976).
CC -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC utilization. Activator of gluconeogenetic genes like acuF, acuG and
CC acuN. {ECO:0000269|PubMed:17339216, ECO:0000269|PubMed:3622}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR EMBL; AY255811; AAQ83291.1; -; Genomic_DNA.
DR EMBL; AACD01000129; EAA62048.1; -; Genomic_DNA.
DR EMBL; BN001304; CBF79440.1; -; Genomic_DNA.
DR RefSeq; XP_680737.1; XM_675645.1.
DR AlphaFoldDB; Q5AW62; -.
DR SMR; Q5AW62; -.
DR STRING; 162425.CADANIAP00000561; -.
DR EnsemblFungi; CBF79440; CBF79440; ANIA_07468.
DR EnsemblFungi; EAA62048; EAA62048; AN7468.2.
DR GeneID; 2869719; -.
DR KEGG; ani:AN7468.2; -.
DR eggNOG; ENOG502R1M5; Eukaryota.
DR HOGENOM; CLU_010748_1_0_1; -.
DR InParanoid; Q5AW62; -.
DR OMA; VMTTCKL; -.
DR OrthoDB; 681770at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Gluconeogenesis; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..702
FT /note="Transcription activator of gluconeogenesis acuK"
FT /id="PRO_0000406439"
FT DNA_BIND 73..101
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 702 AA; 75909 MW; 56D707D8BD6FACDC CRC64;
METETGKGAT APPAESSGVE QDTAAVGAPA DQPPKTNANA TSNANGEDQP ANGQKANPKD
PSRPRRKKAR RACFACQRAH LTCGDERPCQ RCIKRGLQDA CHDGVRKKAK YLHDAPDGAL
MPGIGGNNFY NNNSMSNGVP SGGINMNGAN TVNSAASTQN SSANFYPTPQ SNYSLYQENP
INHQNSFPSQ SPVSPTFSLK TNPTPRNTAP NNNNNNALTS SMPQPATTGV SNAPNQSQNP
FAGPFFDPSD PALFNFDLSS MNFENRYGAL EFGMLGHMAT GAGDSPDSGT HRGSMGRSGS
TQFASTPIGG TTTFGESPQN QQPFMFGDPL LNEWPSGQTS GQPHVNVGVY PQSSQGNVIP
GHLSKPDAPH AFAIESGPNN FTSPGAATSP QINSGGYEDA NAFNNVVTKS NGLSVNGQQR
PPTISTPSLK HQSLQMNKRR HRNPSAVYES VKEPYAYTSR FHSLTAFIQR RFSPQKTLQI
AKALASIRPS FIATTKTLNR DDLIFMEKCF QRTLWEYEDF INACGTPTIV CRRTGEVAAV
GKEFSILTGW KKEVLLGKEP NYNVNTGGSS AANSRNITPR SSVESTGRPH PVFLAELLDD
DSVVEFYEDF ARLAFGDSRG SVTTRCKLLK YKTKEDMEAA QSDDNGQRWN NHLRKGGIAN
EAGMNQLGFK DGKVECAYCW TVKRDVFDIP MLIVMNVRLP LP
