ID   ACUK_NEUCR              Reviewed;         740 AA.
AC   Q7RUA4; Q6M901;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Transcription activator of gluconeogenesis NCU03938;
GN   ORFNames=G17A4.270, NCU03938;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; BX908812; CAF06162.1; -; Genomic_DNA.
DR   EMBL; CM002241; EAA28341.2; -; Genomic_DNA.
DR   RefSeq; XP_957577.2; XM_952484.3.
DR   AlphaFoldDB; Q7RUA4; -.
DR   SMR; Q7RUA4; -.
DR   STRING; 5141.EFNCRP00000003593; -.
DR   EnsemblFungi; EAA28341; EAA28341; NCU03938.
DR   GeneID; 3873715; -.
DR   KEGG; ncr:NCU03938; -.
DR   VEuPathDB; FungiDB:NCU03938; -.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; Q7RUA4; -.
DR   OMA; VMTTCKL; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..740
FT                   /note="Transcription activator of gluconeogenesis NCU03938"
FT                   /id="PRO_0000406443"
FT   DOMAIN          475..546
FT                   /note="PAS"
FT   DNA_BIND        75..103
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..384
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..579
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  79512 MW;  17E212530C626A66 CRC64;
     MPDDVGPAEA EVSGAVSESD NEYDETEVTT KDDDDEKMAE RSVASEGVET NGDQKKKYDP
     KDPLRPRRKK ARRACYACQR AHLTCGDERP CQRCIKRGLA EACQDGVRKK AKYLHDAPPE
     ALRPVLGPNY NPAAAVSVRN GHRHPSNAGS DAGSSIGTFY SQSTQYPVFS SAATQLGSIP
     ENLPFPQQSP VSPTFQPSSN PQLGSIGVSS VSSPMNSFPP ALFDPSNPAI FNFNLEGLNF
     GSQYGAMEFG MLGHMSSGAA ETPPRDPSMA QQGTSDVGFN PSGVFGNGLN QFEKVYDNNT
     GLISDFLTLD AHSNGLYSQG NLQHGLPHAY AIPAGPTSLQ SPSTENNSPQ PTGFGFESPT
     ATNYTGVPGA AGNQPGSQQP RAQKPKTPAL GKLGPQSVLG KRQRDPSSIY EAVKEPFQYV
     ASFHKLISLL QNRFSGASTI SIVRSLASIR PSFMSCMKTL NRADLIFMEK SFQRALFEHE
     EFMHQSPSPA IACRRTGEIA AVNKEFTALT GWTKDVLLGK TLNLNANMGG TNSDTLSISS
     KGGRGGIVGT TPRLKPLHPE QGTNADSQQQ QSQQHKEQPQ PVFLAELMDE ASVTQFYEDY
     AQLAFTHSRG TVVRKCRLLK YRTQENMDAA AAAAAAASAP TASGGSGSSN GTVVNGGPDS
     SPAGKTEKER PTGVNVASNS ILSNRVAKID GEHGISKLER DGKLECSYTW TIKRDVFDIP
     MIIMINFLPC YYRSHNQLAV