ACUK_PARBA
ID ACUK_PARBA Reviewed; 808 AA.
AC C1GR85;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 04-FEB-2015, sequence version 2.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Transcription activator of gluconeogenesis PAAG_01030;
GN ORFNames=PAAG_01030;
OS Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS brasiliensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502779;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-826 / Pb01;
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC utilization. Activator of gluconeogenetic genes (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEH38109.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; KN293993; EEH38109.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015701003.1; XM_015844222.1.
DR AlphaFoldDB; C1GR85; -.
DR SMR; C1GR85; -.
DR STRING; 502779.C1GR85; -.
DR EnsemblFungi; EEH38109; EEH38109; PAAG_01030.
DR GeneID; 9100690; -.
DR KEGG; pbl:PAAG_01030; -.
DR eggNOG; ENOG502R1M5; Eukaryota.
DR HOGENOM; CLU_010748_1_0_1; -.
DR OrthoDB; 681770at2759; -.
DR Proteomes; UP000002059; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..808
FT /note="Transcription activator of gluconeogenesis
FT PAAG_01030"
FT /id="PRO_0000406444"
FT DNA_BIND 97..125
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 86857 MW; F39D0C18BAAD239B CRC64;
MTSSVRNGSP SPSPALPSTT TPAEQESRNA MTMANNPGDW DSSESRPQSL SNGKGIGNGM
VANGHQKPST SSTAASANNA SAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG
LQDTCHDGVR KKAKYLHDAP NEALIPGIRG NLYNQAQAAR NKVNSNSQQR NGTNSNSDNN
STNTNSNNKP SHQDVSTNFF STPSANNYHN VYTQAKSRQS QHMPSRVMQD ATMNPSAFQA
QPPASPTFDL SSNPQNHTLS PSIAQNSGTT PSSSASQNPD PYGSTFFDPS HPALFNFDIA
SMNFGNRYGA LEFGMLGHLA TGAGDTPPSD TATRRGSIGR SSGTFTVQNF GEGSSNQSPF
LFGGDPVLND WNPAGQGPTN PRNIYNQNSV SGQMTDHPHA FAIESAPMNF ASPTSTESPQ
MTTVTQFDDP SVNFSSRTTL MPPTNTQHQQ QPQPPRISTP SLKNMQVGVK RRYRSPSSIY
ESVKEPYSYT SGFHSLTAFI QRRFSPQKTL QIAKALASIR PSFIATTKTL NQDDLIFMEK
CFQRTLWEYE DFIDACGTPT IVCRRTGEIA AVGKEFSILT GWKKEVLLGK EPNLNVNTGG
SSSSGVSSRG SSTYNSRNSA TTTVMDNQSL PAGRTQPVFL AELLDDDSVI EFYEDFAKLA
FGDSRGSVMT TCKLLKYKTK EDGVGLFRNS NGEVSAGGGD TDANDSAGAG VGDGTTTAVN
GVSNGSSNNA TNVNANGNVN VIPNDLSGAS SMKSSPKQAW GKSRIAGEAG MNQLGFRDGK
VECSYCWTVK RDVFDIPMLI VMNFLPCI
