DDIAS_HUMAN
ID DDIAS_HUMAN Reviewed; 998 AA.
AC Q8IXT1; Q96LK6; Q9H856;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=DNA damage-induced apoptosis suppressor protein;
DE AltName: Full=Nitric oxide-inducible gene protein;
GN Name=DDIAS; Synonyms=C11orf82, NOXIN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 158-824 (ISOFORM 1), AND VARIANT SER-460.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS THR-217;
RP SER-460 AND ILE-842.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, INDUCTION, AND FUNCTION.
RX PubMed=24214091; DOI=10.1002/ijc.28600;
RA Won K.J., Im J.Y., Yun C.O., Chung K.S., Kim Y.J., Lee J.S., Jung Y.J.,
RA Kim B.K., Song K.B., Kim Y.H., Chun H.K., Jung K.E., Kim M.H., Won M.;
RT "Human Noxin is an anti-apoptotic protein in response to DNA damage of A549
RT non-small cell lung carcinoma.";
RL Int. J. Cancer 134:2595-2604(2014).
CC -!- FUNCTION: May be an anti-apoptotic protein involved in DNA repair or
CC cell survival. {ECO:0000269|PubMed:24214091}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IXT1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IXT1-2; Sequence=VSP_029606, VSP_029607;
CC -!- TISSUE SPECIFICITY: Highly expressed in colorectal and lung cancer
CC tissues. {ECO:0000269|PubMed:24214091}.
CC -!- INDUCTION: Induced by UV irradiation. Expression starts to increase in
CC early S phase and is steady high until late S phase in both cancer and
CC normal cells. {ECO:0000269|PubMed:24214091}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14764.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK023998; BAB14764.1; ALT_INIT; mRNA.
DR EMBL; AK058145; BAB71685.1; -; mRNA.
DR EMBL; AP001646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039268; AAH39268.1; -; mRNA.
DR CCDS; CCDS8263.1; -. [Q8IXT1-1]
DR RefSeq; NP_659455.3; NM_145018.3. [Q8IXT1-1]
DR RefSeq; XP_011543137.1; XM_011544835.1.
DR RefSeq; XP_011543138.1; XM_011544836.2. [Q8IXT1-1]
DR AlphaFoldDB; Q8IXT1; -.
DR BioGRID; 128620; 13.
DR STRING; 9606.ENSP00000435421; -.
DR iPTMnet; Q8IXT1; -.
DR PhosphoSitePlus; Q8IXT1; -.
DR BioMuta; DDIAS; -.
DR DMDM; 162416238; -.
DR MassIVE; Q8IXT1; -.
DR MaxQB; Q8IXT1; -.
DR PaxDb; Q8IXT1; -.
DR PeptideAtlas; Q8IXT1; -.
DR PRIDE; Q8IXT1; -.
DR ProteomicsDB; 71060; -. [Q8IXT1-1]
DR Antibodypedia; 31345; 52 antibodies from 17 providers.
DR DNASU; 220042; -.
DR Ensembl; ENST00000329143.4; ENSP00000329930.4; ENSG00000165490.13. [Q8IXT1-1]
DR Ensembl; ENST00000525361.5; ENSP00000435424.1; ENSG00000165490.13. [Q8IXT1-2]
DR Ensembl; ENST00000533655.6; ENSP00000435421.1; ENSG00000165490.13. [Q8IXT1-1]
DR GeneID; 220042; -.
DR KEGG; hsa:220042; -.
DR MANE-Select; ENST00000533655.6; ENSP00000435421.1; NM_145018.4; NP_659455.3.
DR UCSC; uc001ozt.4; human. [Q8IXT1-1]
DR CTD; 220042; -.
DR DisGeNET; 220042; -.
DR GeneCards; DDIAS; -.
DR HGNC; HGNC:26351; DDIAS.
DR HPA; ENSG00000165490; Tissue enhanced (bone marrow, testis).
DR MIM; 618045; gene.
DR neXtProt; NX_Q8IXT1; -.
DR OpenTargets; ENSG00000165490; -.
DR PharmGKB; PA162377743; -.
DR VEuPathDB; HostDB:ENSG00000165490; -.
DR eggNOG; ENOG502R2XT; Eukaryota.
DR GeneTree; ENSGT00390000014932; -.
DR HOGENOM; CLU_015113_0_0_1; -.
DR InParanoid; Q8IXT1; -.
DR OMA; WVPPTTK; -.
DR OrthoDB; 259980at2759; -.
DR PhylomeDB; Q8IXT1; -.
DR TreeFam; TF332740; -.
DR PathwayCommons; Q8IXT1; -.
DR BioGRID-ORCS; 220042; 7 hits in 1080 CRISPR screens.
DR ChiTaRS; DDIAS; human.
DR GenomeRNAi; 220042; -.
DR Pharos; Q8IXT1; Tbio.
DR PRO; PR:Q8IXT1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8IXT1; protein.
DR Bgee; ENSG00000165490; Expressed in oocyte and 115 other tissues.
DR ExpressionAtlas; Q8IXT1; baseline and differential.
DR Genevisible; Q8IXT1; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IMP:UniProtKB.
DR GO; GO:0097752; P:regulation of DNA stability; IMP:UniProtKB.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR043522; DDIAS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013955; Rep_factor-A_C.
DR PANTHER; PTHR35537; PTHR35537; 1.
DR Pfam; PF08646; Rep_fac-A_C; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Apoptosis; Cell cycle; Cytoplasm; Growth arrest;
KW Nucleus; Reference proteome.
FT CHAIN 1..998
FT /note="DNA damage-induced apoptosis suppressor protein"
FT /id="PRO_0000311838"
FT REGION 815..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 171..178
FT /note="GIAGFTVI -> ATQDAKTK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029606"
FT VAR_SEQ 179..998
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029607"
FT VARIANT 217
FT /note="I -> T (in dbSNP:rs17853911)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037326"
FT VARIANT 460
FT /note="R -> S (in dbSNP:rs7947780)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_037327"
FT VARIANT 757
FT /note="D -> N (in dbSNP:rs35711622)"
FT /id="VAR_037328"
FT VARIANT 795
FT /note="P -> R (in dbSNP:rs11826199)"
FT /id="VAR_037329"
FT VARIANT 842
FT /note="V -> I (in dbSNP:rs7130899)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037330"
FT CONFLICT 153
FT /note="H -> R (in Ref. 1; BAB71685)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 998 AA; 111616 MW; C1BAEB360CD04559 CRC64;
MNRRRKFLLA SVLALQNSSF IYPSCQKCFS RIILVSKRSN CPKCGSTGES GNANYRYKLS
LKVAESNKLF VITVFGSCLD TFFGLTATGL HRYIQDPNKI PETLDNDTTQ NLLTKAVETC
FVGQSFIFGV TNFENQPGQG SDASNFLQQC SDHKRKAKAL VACQIVLPDP GIAGFTVIDY
FHQLLQTFNF RKLQCDSQAP NNHLLALDHS NSDLSSIYTS DSTSDFFKSC SKDTFSKFWQ
PSLEFTCIVS QLTDNDDFSA SEQSKAFGTL QQNRKSISIA EATGSSSCHD PIQDSWSLVS
YMDKKSTAEK LGKELGLQAK ELSAVHSSHH EIGVNDSNLF SLEMREPLES SNTKSFHSAV
EIKNRSQHEL PCFQHHGIDT PTSLQKRSAC CPPSLLRLEE TASSSQDGDP QIWDDLPFSE
SLNKFLAVLE SEIAVTQADV SSRKHHVDND IDKFHADHSR LSVTPQRTTG ALHTPPIALR
SSQVIVKANC SKDDFLFNCK GNLSPSVEKE SQPDNKVEAV SVNHNGRDMS EYFLPNPYLS
ALSSSSKDLE TIVTLKKTIR ISPHRESDHS SLNNKYLNGC GEISVSEMNE KLTTLCYRKY
NDVSDLCKLE NKQYCRWSKN QDDSFTICRK LTYPLETLCN SPNRSTNTLK EMPWGHINNN
VTQSYSIGYE GSYDASADLF DDIAKEMDIA TEITKKSQDI LLKWGTSLAE SHPSESDFSL
RSLSEDFIQP SQKLSLQSLS DSRHSRTCSP TPHFQSDSEY NFENSQDFVP CSQSTPISGF
HQTRIHGINR AFKKPVFYSD LDGNYEKIRI FPENDKQQAS PSCPKNIKTP SQKIRSPIVS
GVSQPDVFNH YPFAECHETD SDEWVPPTTQ KIFPSDMLGF QGIGLGKCLA AYHFPDQQEL
PRKKLKHIRQ GTNKGLIKKK LKNMLAAVVT KKKTHKYNCK SSGWISKCPD IQVLAAPQLH
PILGPDSCSE VKCCLPFSEK GPPSVCETRS AWSPELFS
