DDIAS_MOUSE
ID DDIAS_MOUSE Reviewed; 898 AA.
AC Q6NZG4; A2T1E9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=DNA damage-induced apoptosis suppressor protein;
DE AltName: Full=Nitric oxide-inducible gene protein;
GN Name=Ddias; Synonyms=Noxin;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=17515607; DOI=10.1128/mcb.00551-06;
RA Nakaya N., Hemish J., Krasnov P., Kim S.Y., Stasiv Y., Michurina T.,
RA Herman D., Davidoff M.S., Middendorff R., Enikolopov G.;
RT "noxin, a novel stress-induced gene involved in cell cycle and apoptosis.";
RL Mol. Cell. Biol. 27:5430-5444(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CD-1; TISSUE=Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be an anti-apoptotic protein involved in DNA repair or
CC cell survival. {ECO:0000269|PubMed:17515607}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17515607}. Nucleus
CC {ECO:0000269|PubMed:17515607}. Note=Accumulates in the nucleus in
CC response to stress.
CC -!- TISSUE SPECIFICITY: Highly expressed in the testis, spleen and heart.
CC Expressed at high levels in the primary spermatocytes and to a lesser
CC extent in the round spermatids. Also found in the bone marrow, brain,
CC lung, kidney and liver. {ECO:0000269|PubMed:17515607}.
CC -!- INDUCTION: Strongly induced by a wide range of stress signals: nitric-
CC oxide, gamma- and UV irradiation, hydrogen peroxide, adriamycin and
CC cytokines and this induction is dependent on p53/TP53. Expression is
CC low in resting cells and increases almost 50-fold as the cells progress
CC through the S phase. {ECO:0000269|PubMed:17515607}.
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DR EMBL; DQ400346; ABD63254.1; -; mRNA.
DR EMBL; BC066148; AAH66148.1; -; mRNA.
DR AlphaFoldDB; Q6NZG4; -.
DR STRING; 10090.ENSMUSP00000032877; -.
DR iPTMnet; Q6NZG4; -.
DR PhosphoSitePlus; Q6NZG4; -.
DR PaxDb; Q6NZG4; -.
DR PRIDE; Q6NZG4; -.
DR ProteomicsDB; 279177; -.
DR MGI; MGI:1921291; Ddias.
DR eggNOG; ENOG502R2XT; Eukaryota.
DR InParanoid; Q6NZG4; -.
DR PhylomeDB; Q6NZG4; -.
DR PRO; PR:Q6NZG4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6NZG4; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IMP:MGI.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI.
DR GO; GO:0071480; P:cellular response to gamma radiation; IMP:MGI.
DR GO; GO:0071447; P:cellular response to hydroperoxide; IMP:MGI.
DR GO; GO:0034644; P:cellular response to UV; IMP:MGI.
DR GO; GO:0044346; P:fibroblast apoptotic process; IMP:MGI.
DR GO; GO:0030097; P:hemopoiesis; IMP:MGI.
DR GO; GO:2000270; P:negative regulation of fibroblast apoptotic process; IMP:MGI.
DR GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; ISO:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; IDA:MGI.
DR GO; GO:0097752; P:regulation of DNA stability; ISO:MGI.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR CDD; cd04476; RPA1_DBD_C; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR043522; DDIAS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013955; Rep_factor-A_C.
DR PANTHER; PTHR35537; PTHR35537; 1.
DR Pfam; PF08646; Rep_fac-A_C; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell cycle; Cytoplasm; Growth arrest; Nucleus;
KW Reference proteome.
FT CHAIN 1..898
FT /note="DNA damage-induced apoptosis suppressor protein"
FT /id="PRO_0000311839"
FT REGION 191..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 95
FT /note="G -> E (in Ref. 1; ABD63254)"
FT /evidence="ECO:0000305"
FT CONFLICT 676
FT /note="D -> G (in Ref. 1; ABD63254)"
FT /evidence="ECO:0000305"
FT CONFLICT 785
FT /note="P -> H (in Ref. 1; ABD63254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 898 AA; 99945 MW; 0D02706E7AA489DD CRC64;
MNKRRKFLFA SVLAVQNSNF IYPSCQRCFS KIILESKRFT CPKCGSSGDT GSTNYRYKLS
LKVAESSKLF FITVFGSCLD TFFGLTATGL HRYLGDSIKN LETLDSGRTQ SLLTTAVEKC
FVGQSFVFGV TNFGDVCGHD SDSSNFQQPC CKHRGEVRTL VASQIILPSP HVKGFTVIAY
LHPLLHKKPH CGSQEHSSQS LTSDDSDSDL NNIQGSGNTS WFSESSVGED FFRYWEPSLE
LTSSDSQVTS SDDFPASKQI MASGTPNQNR HCISVSEVTS SKNCHDSLQS LWSLHSCMDK
NNTTGKLGEE LGLPSPVCNS CHESRLSDSH FFPSQMQEPF EEHNLECYSK AEKNDYSQYD
IACYQHHEVN TTPILQQRSS AFSLSSLKPE ETANPSQNSD SLIWDDLPLS ESLNKFLAVV
ESEVAVTEID AKNRKQGMDK SIDKCHKNYS RLSLTPWRNT RALNTSCFSL RSSQAMMKDS
GKEALFSNCK SNSSPHIQKE SKADKTEAAV SIAGSRSDIS EDFLPDTCSS ALFTSSKDRE
AFITQKRTSG VLQQRNEISC RPSTSISDCS DLRSRYFTGC GQKLHSGTKG KLAIQNCSKK
YSDASDLHKL ENKHRWPKKE DDNFTICRKL TYPLETLCSS PESINTSKEM PYRPSNNNLT
PSSSGDHEGS YNASADLFDY IAKDKDIGTE ITKIPQDNLL PLEVPCTENY PINENRGQPS
QKPSLQSISP SRYSRPRSQS DSECDFEESQ DFVPCSQSTP VAGFHQRIHG LNGASKILPS
IYSNPNANYK NRKNSPLTGQ YQATSACSKN VKAFRQKPES PFVSSLTQAN VFNHCPAAES
LGNDVDEWVP PTTKKVFISD ILGFRVMGLR KCLDLHYSPD PKELPRKKLI KVTHKTNI
