ACUK_PARBD
ID ACUK_PARBD Reviewed; 814 AA.
AC C1G966;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 04-FEB-2015, sequence version 2.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Transcription activator of gluconeogenesis PADG_03802;
GN ORFNames=PADG_03802;
OS Paracoccidioides brasiliensis (strain Pb18).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX NCBI_TaxID=502780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pb18;
RX PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT "Comparative genomic analysis of human fungal pathogens causing
RT paracoccidioidomycosis.";
RL PLoS Genet. 7:E1002345-E1002345(2011).
CC -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC utilization. Activator of gluconeogenetic genes (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEH47718.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; KN275960; EEH47718.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_010759184.1; XM_010760882.1.
DR AlphaFoldDB; C1G966; -.
DR SMR; C1G966; -.
DR STRING; 121759.XP_010759184.1; -.
DR EnsemblFungi; EEH47718; EEH47718; PADG_03802.
DR GeneID; 22583044; -.
DR KEGG; pbn:PADG_03802; -.
DR eggNOG; ENOG502R1M5; Eukaryota.
DR HOGENOM; CLU_010748_1_0_1; -.
DR Proteomes; UP000001628; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..814
FT /note="Transcription activator of gluconeogenesis
FT PADG_03802"
FT /id="PRO_0000406445"
FT DNA_BIND 97..125
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 87309 MW; 4E6F06F941B52EA6 CRC64;
MTSSARNGSP SPSPALPSTT TPAEQESRNT MTTANNPGDW DSSESRPQPL SNGKGVGNGM
VANGHQRPST SSTAASANNA SAKDPLRPRR KKAKRACFAC QRAHLTCGDE RPCQRCIKRG
LQDTCHDGVR KKAKYLHDAP NEALIPGIRG NLYSQAQAAR NKINTNSQQR NGTNSNSDNN
STNTNSNNKP SHQDVSTNFF STPSTNNYNT VYTQAKSRQS QHMPSRVMQD ATMNPSAFQA
QPPASPTFDL SSNPQNHTLS PSMAQNSGTT PSSSASQNPD PYGPTFFDPS HPALFNFDIA
SMNFGNRYGA LEFGMLGHLA TGAGDTPPSD SATRRGSIGR SSGTFTVQNF GEGSSNQSPF
LFGGDPVLND WNPAGQGQTN SRNIYNQNSV SGQMADHPHA FAIESAPMNF ASPSSTESPQ
MTTVTQFDDP SVNFSSRTTL MPPTNTQHQQ QPQPPRISTP SLKNMQVGVK RRYRSPSSIY
ESVKEPYSYT SGFHSLTAFI QRRFSPQKTL QIAKALASIR PSFIATTKTL NQDDLIFMEK
CFQRTLWEYE DFIDACGTPT IVCRRTGEIA AVGKEFSILT GWKKEVLLGK EPNLNVNTGG
SSSSGVSSRG SSTYNSRNSA TMTVMDNQSL PTGRTQPVFL AELLDDDSVI EFYEDFAKLA
FGDSRGSVMT TCKLLKYKTK EDGVGLFRNS NGEVSAAGGG GTAADDTDAN DGAGAGAGDG
TTSAVNGVSN GSGNNATNVN ANGNVNVIPN DLSGASSMKL SPKQAWGKSR IAGEAGMNQL
GFRDGKVECS YCWTVKRDVF DIPMLIVMNF LPCI
