ID   DDIT4_DANRE             Reviewed;         220 AA.
AC   Q7T346;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA damage-inducible transcript 4 protein;
GN   Name=ddit4; ORFNames=zgc:64114;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates cell growth, proliferation and survival via
CC       inhibition of the activity of the mammalian target of rapamycin complex
CC       1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves
CC       ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an
CC       important role in responses to cellular energy levels and cellular
CC       stress, including responses to hypoxia and DNA damage, via its effect
CC       on mTORC1 activity. Plays a role in neuronal differentiation, neuron
CC       migration during embryonic brain development and in neuronal cell death
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR   EMBL; BC053258; AAH53258.1; -; mRNA.
DR   RefSeq; NP_956401.1; NM_200107.2.
DR   AlphaFoldDB; Q7T346; -.
DR   SMR; Q7T346; -.
DR   STRING; 7955.ENSDARP00000127401; -.
DR   PaxDb; Q7T346; -.
DR   Ensembl; ENSDART00000054788; ENSDARP00000054787; ENSDARG00000037618.
DR   Ensembl; ENSDART00000152899; ENSDARP00000127401; ENSDARG00000037618.
DR   GeneID; 378866; -.
DR   KEGG; dre:378866; -.
DR   CTD; 54541; -.
DR   ZFIN; ZDB-GENE-031002-35; ddit4.
DR   eggNOG; ENOG502RB72; Eukaryota.
DR   GeneTree; ENSGT00530000063652; -.
DR   HOGENOM; CLU_086145_1_0_1; -.
DR   InParanoid; Q7T346; -.
DR   OMA; FFDPMEE; -.
DR   OrthoDB; 1588396at2759; -.
DR   PhylomeDB; Q7T346; -.
DR   TreeFam; TF105007; -.
DR   Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR   PRO; PR:Q7T346; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000037618; Expressed in early embryo and 47 other tissues.
DR   ExpressionAtlas; Q7T346; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0071889; F:14-3-3 protein binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0032006; P:regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   Gene3D; 3.90.470.40; -; 1.
DR   InterPro; IPR012918; RTP801-like.
DR   InterPro; IPR038281; RTP801-like_C_sf.
DR   PANTHER; PTHR12478; PTHR12478; 1.
DR   Pfam; PF07809; RTP801_C; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..220
FT                   /note="DNA damage-inducible transcript 4 protein"
FT                   /id="PRO_0000307200"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   220 AA;  23976 MW;  2B79D4F0C214968F CRC64;
     MQDQLISSLS SEDSSPSTPT SDAPAKRLSW SKLMQKLHSS QSLDSDSDNH SSTDDSSDSG
     SICIPDVSQS EFFDPTEEAL CKEVVQLIAL NLTDAKDGVL HCSKLLIPEK LLEHIGQELV
     HLSVSEPCGL RGALIDLCVE QDGSCHAAAQ IAVDPYLVPT FQLTLVLRLD SRGLWPKIQG
     LFTGRSPASP AVRRALRLST GFRAIKRKLY SSEELLIEEC