ID   DDIT4_XENLA             Reviewed;         219 AA.
AC   Q7SYV9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=DNA damage-inducible transcript 4 protein;
DE   AltName: Full=Protein regulated in development and DNA damage response 1;
DE            Short=REDD-1;
GN   Name=ddit4; Synonyms=redd1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=12453409; DOI=10.1016/s1097-2765(02)00706-2;
RA   Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K.,
RA   Oliner J.D., McKeon F., Haber D.A.;
RT   "REDD1, a developmentally regulated transcriptional target of p63 and p53,
RT   links p63 to regulation of reactive oxygen species.";
RL   Mol. Cell 10:995-1005(2002).
CC   -!- FUNCTION: Regulates cell growth, proliferation and survival via
CC       inhibition of the activity of the mammalian target of rapamycin complex
CC       1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves
CC       ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an
CC       important role in responses to cellular energy levels and cellular
CC       stress, including responses to hypoxia and DNA damage, via its effect
CC       on mTORC1 activity. Plays a role in neuronal differentiation, neuron
CC       migration during embryonic brain development and in neuronal cell death
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR   EMBL; BC054246; AAH54246.1; -; mRNA.
DR   RefSeq; NP_001079791.1; NM_001086322.1.
DR   AlphaFoldDB; Q7SYV9; -.
DR   SMR; Q7SYV9; -.
DR   DNASU; 379481; -.
DR   GeneID; 379481; -.
DR   KEGG; xla:379481; -.
DR   CTD; 379481; -.
DR   Xenbase; XB-GENE-944281; ddit4.S.
DR   OMA; EDEYANM; -.
DR   OrthoDB; 1588396at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 379481; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 3.90.470.40; -; 1.
DR   InterPro; IPR012918; RTP801-like.
DR   InterPro; IPR038281; RTP801-like_C_sf.
DR   PANTHER; PTHR12478; PTHR12478; 1.
DR   Pfam; PF07809; RTP801_C; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..219
FT                   /note="DNA damage-inducible transcript 4 protein"
FT                   /id="PRO_0000307201"
SQ   SEQUENCE   219 AA;  24180 MW;  3FDB56B4BE45989D CRC64;
     MPARWDAFSA LSVPPPILEE ESPSQFWGED CANVAQRCSS LPSSDCESLT SSNSYSECDL
     DAWDEISIPD SELLNDPEGE QLCPSLLKLI NRCLTKARIN SLRCSRLLIP DELLCNLGQE
     LLHLAYSEPC GLRGALIDLC VENGKDCHSV AQITVDQAVV PTFQLTVLLR LDSRLWPRIQ
     GLFSTKPVPG SGQSLKLSPG FKVLKKKLYS SEELIIEEC