ID   DDIT4_XENTR             Reviewed;         219 AA.
AC   Q6P4J6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA damage-inducible transcript 4 protein;
DE   AltName: Full=Protein regulated in development and DNA damage response 1;
DE            Short=REDD-1;
GN   Name=ddit4; Synonyms=redd1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates cell growth, proliferation and survival via
CC       inhibition of the activity of the mammalian target of rapamycin complex
CC       1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves
CC       ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an
CC       important role in responses to cellular energy levels and cellular
CC       stress, including responses to hypoxia and DNA damage, via its effect
CC       on mTORC1 activity. Plays a role in neuronal differentiation, neuron
CC       migration during embryonic brain development and in neuronal cell death
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR   EMBL; BC063371; AAH63371.1; -; mRNA.
DR   RefSeq; NP_989175.1; NM_203844.1.
DR   AlphaFoldDB; Q6P4J6; -.
DR   SMR; Q6P4J6; -.
DR   STRING; 8364.ENSXETP00000056596; -.
DR   PaxDb; Q6P4J6; -.
DR   DNASU; 394782; -.
DR   Ensembl; ENSXETT00000083124; ENSXETP00000099461; ENSXETG00000037163.
DR   GeneID; 394782; -.
DR   KEGG; xtr:394782; -.
DR   CTD; 54541; -.
DR   Xenbase; XB-GENE-944276; ddit4.
DR   eggNOG; ENOG502RB72; Eukaryota.
DR   HOGENOM; CLU_086145_1_0_1; -.
DR   InParanoid; Q6P4J6; -.
DR   OMA; EQGKGCH; -.
DR   OrthoDB; 1588396at2759; -.
DR   PhylomeDB; Q6P4J6; -.
DR   TreeFam; TF105007; -.
DR   Reactome; R-XTR-5628897; TP53 Regulates Metabolic Genes.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000037163; Expressed in blastula and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0071889; F:14-3-3 protein binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0032006; P:regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   Gene3D; 3.90.470.40; -; 1.
DR   InterPro; IPR012918; RTP801-like.
DR   InterPro; IPR038281; RTP801-like_C_sf.
DR   PANTHER; PTHR12478; PTHR12478; 1.
DR   Pfam; PF07809; RTP801_C; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Mitochondrion; Reference proteome.
FT   CHAIN           1..219
FT                   /note="DNA damage-inducible transcript 4 protein"
FT                   /id="PRO_0000307202"
SQ   SEQUENCE   219 AA;  24277 MW;  E4183465CF71E38C CRC64;
     MPARWDTFSA LSVPPPILEE EPQSQFWGED CADVSQRCSS LPSSDCESLT SSNSYSECDL
     DAWDEISLPD SELLNDPEGE QLCPSLLKLI KRCLTKAKIN SLRCSRLLIP DELLCNLGQE
     LLHLAYSEPC GLRGALIDLC VEHGKDCHSV AQITVDQAVV PTFQLTVLLR LDSRLWPRIQ
     GLFSTKPVPG SGQSLKLSPG FKVLKKKLYS SEELIIEEC