ID   ACUK_PENRW              Reviewed;         694 AA.
AC   B6HSQ3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Transcription activator of gluconeogenesis Pc22g08580;
GN   ORFNames=Pc22g08580;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; AM920437; CAP98146.1; -; Genomic_DNA.
DR   RefSeq; XP_002564870.1; XM_002564824.1.
DR   AlphaFoldDB; B6HSQ3; -.
DR   SMR; B6HSQ3; -.
DR   STRING; 1108849.XP_002564870.1; -.
DR   EnsemblFungi; CAP98146; CAP98146; PCH_Pc22g08580.
DR   GeneID; 8305670; -.
DR   KEGG; pcs:Pc22g08580; -.
DR   VEuPathDB; FungiDB:PCH_Pc22g08580; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   BioCyc; PCHR:PC22G08580-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c22.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..694
FT                   /note="Transcription activator of gluconeogenesis
FT                   Pc22g08580"
FT                   /id="PRO_0000406446"
FT   DNA_BIND        65..93
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..581
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  75410 MW;  9FC00E9A5AE3ED94 CRC64;
     MNMETKNGSP VPAGDYSGER DSADITEHEQ MDVKPKTNGD SKADRKAANA KDPSRPRRKK
     ARRACFACQR AHLTCGDERP CQRCIKRGLQ DACHDGVRKK AKYLHDAPDG ALMPAVSSNT
     NLYNNTLRNN LPISRNGTNA VNSNQQHSQQ HPQQPTNPTN NNFYPTPQTQ TGSYNPYQES
     SMGQSPFTTQ SPVSPTFNMK SSTNGRNPSL SSTVNQQPTP STALSGDTSQ SQNPFAGPFF
     DPSDPALFNF DLSSMNFENR YGALEFGMLG HMATGAAGDS PTDSAGQRGS IGRSGSAQFS
     TPAPGFGESP GNQPFMFGDP LLNEWSAGPA SGQHVNVGGV YAPNTMLPEH MKANAPHAFA
     IESGPASFTS PGSAPSPNIP TAAFDDGPFN NIAPAPKSNS LVPNGQRQVT ASILKHPNLQ
     VGPKRRHRNP SSIYESVKEP YAYTSGFHNL TAFIQRRFTP QKTVRIAKAL ASIRPSFIAT
     TKTLNRDDLI FMEKCFQRTL WEYEDFINAC GTPTIVCRRT GEIAAVGKEF SILTGWKKDV
     LLGKETNLNV NTGGSAVPQS GTTSRGSFTP RGSTLENSGT GRPQPVFLAE LLDDDSVVEF
     YEDFARLAFG DSRGSVMTRC KLLKYKTKED MEVAQSDDNG KWNNHLRKGG IAGEAGMNQL
     GFKDGKVDCA YCWTVKRDVF DIPMLIVMNF LPCI