ID   ACUK_SCLS1              Reviewed;         521 AA.
AC   A7EAG1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Transcription activator of gluconeogenesis SS1G_02293;
GN   ORFNames=SS1G_02293;
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; CH476623; EDN99439.1; -; Genomic_DNA.
DR   RefSeq; XP_001596077.1; XM_001596027.1.
DR   AlphaFoldDB; A7EAG1; -.
DR   SMR; A7EAG1; -.
DR   STRING; 665079.A7EAG1; -.
DR   EnsemblFungi; EDN99439; EDN99439; SS1G_02293.
DR   GeneID; 5492583; -.
DR   KEGG; ssl:SS1G_02293; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; A7EAG1; -.
DR   OMA; VMTTCKL; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..521
FT                   /note="Transcription activator of gluconeogenesis
FT                   SS1G_02293"
FT                   /id="PRO_0000406451"
FT   DOMAIN          426..497
FT                   /note="PAS"
FT   DNA_BIND        84..112
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  56546 MW;  C4DAADE72D89F932 CRC64;
     MSGETEIDDP EVSDGASEND YSDHEQELDV VGKEDDNQEM AEQKVRPDGD ENGNTVGAAA
     TATKPKFDPK DPLRPRRKKA RRACFACQRA HLTCGDERPC QRCIKRGLAD ACQDGVRKKA
     KYLHDAPPEA LRPVLGPTYN QQVSNNRATA ASTPTEPSTG MGNFFTQPDT SPSYPLFAAN
     QQGQMPPPLQ NRLSFGSNQP SPISPTFHTV GNRPAGMQGI SLPQVSNDSH AAFGGGAFFD
     PSNPALFNFD LEGLNFGNHY GALEFGMLGH MASGSAETPP QDSSAGMPQN VGDLGYNNNP
     AFNNNPPFNQ IYSHDALPDF AVAPPGAHRP AKRQDTKSGP SGKLGPSSAL GKRNRDPSSI
     YDTVHEPYSY TTGFHSLTAF IQKRFSPNKT LRIAKSLASI RPSFISCTKT LNRQDLVFME
     KCFQRTLFEY EDFMLNCCTP TLVCRRTGEI AAVNKEFTLL TGWRKEVLLG NEPNLNINTG
     NSGASSSGSS GRGSFTTPRM RPINLVDSNT ASLNSTKILQ D