ID   ACUK_SORMK              Reviewed;         738 AA.
AC   D1ZRZ5; F7W633;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Transcription activator of gluconeogenesis SMAC_06113;
GN   ORFNames=SMAC_06113;
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=771870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S.,
RA   Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT   Sordaria macrospora, a model organism for fungal morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCC12971.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CCC12971.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CABT02000033; CCC12971.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; D1ZRZ5; -.
DR   STRING; 771870.D1ZRZ5; -.
DR   EnsemblFungi; CCC12971; CCC12971; SMAC_06113.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; D1ZRZ5; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..738
FT                   /note="Transcription activator of gluconeogenesis
FT                   SMAC_06113"
FT                   /id="PRO_0000406452"
FT   DOMAIN          475..546
FT                   /note="PAS"
FT   DNA_BIND        74..102
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        562..579
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..657
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   738 AA;  79145 MW;  9A85C15FCC05B8E6 CRC64;
     MPDDVGPAEA EVSGAVSESD NEYDETEATT KDDDEKMAER SAASEGVETN GDQKKKYDPK
     DPLRPRRKKA RRACYACQRA HLTCGDERPC QRCIKRGLAE ACQDGVRKKA KYLHDAPPEA
     LRPVLGPNYN PAAAVSVRNG HRHPSNAGSD AGSSVGTFFS QSTQYPVFSS AATQLGSIPE
     NLPFPQQSPV SPTFQASGNP QLGSIGVNSV SSPMNSFPPA LFDPSNPAIF NFNLEGLNFG
     SQYGAMEFGM LGHMSSGAAE TPPRDPSISQ QGTAGDVGFN PSGVFGNGLN QFDKVYDNNT
     GLMSDFLTLD AHSSGLYSQG NLQHGLPHAY AIPAGPTSLQ SPSTENNSPQ PTGFGFESPT
     TTNYTGVPGA GGNQPGSQQS RTQKPKTPAL GKLGPQSVLG KRQRDPSSIY EAVKEPFQYV
     ASFHKLISLL QNRFSGASTI SIVRSLASIR PSFMSCMKTL NRADLIFMEK SFQRALFEHE
     EFMHQSPSPA IACRRTGEIA GVNKEFTALT GWTKDVLLGK TLNLNANMGG TNSDTLSVSS
     KGGRGGIVGT TPRLKPLNPE QGPNADGQQQ QSQQQKEQPQ PVFLAELMDE ASVTQFYEDY
     AQLAFTHSRG TVVRKCRLLK YRTQENMDAA AAAASSVPTT AGGSGSSNGT VVNGGPDSSP
     AGKTERERST GANVASNSIL SNRVAKIDGE HGISKLERDG KLECSYTWTI KRDVFDIPMI
     IMINFLPCYY RSHNQLAV