ID   ACUK_TALMQ              Reviewed;         674 AA.
AC   B6Q3B6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Transcription activator of gluconeogenesis PMAA_028970;
GN   ORFNames=PMAA_028970;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; DS995899; EEA28080.1; -; Genomic_DNA.
DR   RefSeq; XP_002144595.1; XM_002144559.1.
DR   AlphaFoldDB; B6Q3B6; -.
DR   STRING; 441960.B6Q3B6; -.
DR   EnsemblFungi; EEA28080; EEA28080; PMAA_028970.
DR   GeneID; 7022350; -.
DR   KEGG; tmf:PMAA_028970; -.
DR   VEuPathDB; FungiDB:PMAA_028970; -.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   OrthoDB; 681770at2759; -.
DR   PhylomeDB; B6Q3B6; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..674
FT                   /note="Transcription activator of gluconeogenesis
FT                   PMAA_028970"
FT                   /id="PRO_0000406447"
FT   DNA_BIND        52..80
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..545
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  72703 MW;  B31DC137B322DD7D CRC64;
     MMDTDKDDLP SATDHSEHES GDAVKVEGGA SKTASNSKDP SRPRRKKARR ACFACQRAHL
     TCGDERPCQR CIKRGLQDAC HDGVRKKAKY LHDAPDGALV PGAQGNFYNQ ANGLPKISPT
     EYTQNGTNNA QQQQQKSGTI YASSTPSYNN NNGTFDTNNA TNTVLPDSAA LNPGPFTATP
     ASPTFSISTS SAMPSLTQPT NDMTSGAGQG SFGAFFDPSD PALFNFDLAS MNFGNRYGAL
     EFGMLGHMAT GAGDTPPSDN GNQRGGSVGQ RSNSQQFGNP PGAFTTESPS QQSFMFGDPV
     LNDWSGGQNT NPRMNVGSGL YGQGGGGGGG MHLLQQDAPH AYAIGSNTFA SPSSTTSPHA
     TTIAPSQFDD SPMKTKTVIS TPHLRQQSLY NSNSNKRRHR EPSAIYDSVK EPYSYTGGFH
     KLIAFIKRRF SPPKTVRIAK ALASIRPSFI ATTKTLNQDD LIFMEKCFQR TLWEYEDFIN
     ACGTPTIVCR RTGEVAAVGK EFSILTGWKK EVLLGKEPNL NVNTGGGNNT SSQSDSTSSS
     IRGGAGGRMR NQEPGPNNMA PVFLAELLDD DSVIEFYEDF ARLAFGDSRG SVMNTCKLLK
     YKTKEDMDSV NADDSRWNSA MTHHIVGKGG IVGEAGMNRL GFKDGRVECS YCWTVKRDVF
     DIPMLIVMNF LPHI