ID   ACUK_TALSN              Reviewed;         662 AA.
AC   B8LT44;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Transcription activator of gluconeogenesis TSTA_069700;
GN   ORFNames=TSTA_069700;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; EQ962652; EED23552.1; -; Genomic_DNA.
DR   RefSeq; XP_002340939.1; XM_002340898.1.
DR   AlphaFoldDB; B8LT44; -.
DR   SMR; B8LT44; -.
DR   STRING; 441959.B8LT44; -.
DR   EnsemblFungi; EED23552; EED23552; TSTA_069700.
DR   GeneID; 8101230; -.
DR   VEuPathDB; FungiDB:TSTA_069700; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; B8LT44; -.
DR   OMA; VMTTCKL; -.
DR   OrthoDB; 681770at2759; -.
DR   PhylomeDB; B8LT44; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..662
FT                   /note="Transcription activator of gluconeogenesis
FT                   TSTA_069700"
FT                   /id="PRO_0000406453"
FT   DNA_BIND        52..80
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          343..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..533
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  71646 MW;  2BEDFD547D4BEA79 CRC64;
     MMDTEKDDLP SATDHSEHES CDIPKTGGTT SKTASNSKDP SRPRRKKARR ACFACQRAHL
     TCGDERPCQR CIKRGLQDAC HDGVRKKAKY LHDAPDGALV PGAQGNFYNQ ANGLSKMSPS
     DFTPNGTNNI QQPKTSSIYA SSTPSYNSNS TFDASSATNP SLPDSAALNP GPFTATPASP
     TFSISASSAM PALTQPANEM TTGAGQNSFG AFFDPSDPAL FNFDLASMNF GNRYGALEFG
     MLGHMATGAG DTPPSDSGNQ RGGSIGQRSN SQQFGNPTGA FTTESPNQQS FMFGDPVLND
     WSGAQNTNPR MSVGGTLYGQ GGGMHLLQQD APHAYAIGSN TFASPSSTTS PHATTIAPSN
     FDDSPMKTKT VISTPHLRQQ SLYNANVNKR RHREPSQIYD SVKEPYSYTG GFHKLIAFIK
     RRFSPPKTVR IAKALASIRP SFIATTKTLN QDDLIFMEKC FQRTLWEYED FINACGTPTI
     VCRRTGEVAA VGKEFSILTG WKKEVLLGKE PNLNVNTGGG TNPSSQTDSA ASSIRGGAGR
     MRNPEPITTN TAPVFLAELL DDDSVIEFYE DFARLAFGDS RGSVMNTCKL LKYKTKEDMD
     LVKSDDGRWN SHIVGKGGIV GEAGMNRLGF RDGRVECSYC WTVKRDVFDI PMLIVMNFLP
     HI