ID   ACUK_TRIVH              Reviewed;         727 AA.
AC   D4D2Y6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Transcription activator of gluconeogenesis TRV_01442;
GN   ORFNames=TRV_01442;
OS   Trichophyton verrucosum (strain HKI 0517).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HKI 0517;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; ACYE01000078; EFE43765.1; -; Genomic_DNA.
DR   RefSeq; XP_003024376.1; XM_003024330.1.
DR   AlphaFoldDB; D4D2Y6; -.
DR   SMR; D4D2Y6; -.
DR   EnsemblFungi; EFE43765; EFE43765; TRV_01442.
DR   GeneID; 9579515; -.
DR   KEGG; tve:TRV_01442; -.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   Proteomes; UP000008383; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..727
FT                   /note="Transcription activator of gluconeogenesis
FT                   TRV_01442"
FT                   /id="PRO_0000406454"
FT   DNA_BIND        65..93
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..567
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        635..661
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   727 AA;  78738 MW;  91CDF646BE2E47AB CRC64;
     MSPHQTTGQE SDNMTVNGEN AQASSQYIQS NEEMTDTIAT EKKASAAKAA KDPSRPKRKK
     AKRACYACQR GHLTCGDERP CQRCIKRGFQ DACHDGVRKK AKYLHDAPNE ALMAGVGATL
     YNQRNTAQNN VNASNTSPGA PQQITSPNFY NTQQSPDYNG FPQNKTELQD STVGPDNYAS
     QSPVSPTYQI SQGLSTQGLS PSLPQSTSET PSAANPAPGQ FNSTFFDPSD PALFNFDLAS
     MNFGNHYGAL EFGMLGHMAT GVGDTPPSDS GAQRGSIGQN GSGTFGLTGS SFSESPSNQA
     PYLFSESGMN DWTQTAPVNR RSMYGSNANL VAGNMSDKPH AFAIESAPAN FASPASNESP
     MMTTSSATFE DTTNSGAFNS RQNVPVSQQR QQPVVSTPQL KQQNLNLGSR RRHKNASSIY
     DSVKDPYSYT SGFHSLTAFI QRRFSPQKTL RIAKALASIR PSFIATTKTL NRDDLIFMEK
     CFQRTLWEYE DFINACGTPT IVCRRTGEIA AVGKEFSILT GWKKEVLLGK EPNHNVNTGG
     SSGLMTGSTS RGSYTPRPYS SEVYNSSATA TPRTQPVFLA ELLDDDSVIE FYEDFAKLAF
     GDSRGSVMTT CKLLKYKTKA ESDILAGSNG EADAGLNGEA TSNETNELNG SHTNGATTNG
     RGQRRWGKGE IAGEAGMNQL GFRDGKVECS YCWTVKRDVF DIPMLIVMNV SCLFLEPLRS
     RAMTDIN