ID   ACUK_UNCRE              Reviewed;         714 AA.
AC   C4JFE4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Transcription activator of gluconeogenesis UREG_00958;
GN   ORFNames=UREG_00958;
OS   Uncinocarpus reesii (strain UAMH 1704).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX   NCBI_TaxID=336963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 1704;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. Activator of gluconeogenetic genes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EEP76109.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CH476615; EEP76109.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_002541442.1; XM_002541396.1.
DR   AlphaFoldDB; C4JFE4; -.
DR   SMR; C4JFE4; -.
DR   STRING; 336963.C4JFE4; -.
DR   EnsemblFungi; EEP76109; EEP76109; UREG_00958.
DR   GeneID; 8441777; -.
DR   KEGG; ure:UREG_00958; -.
DR   eggNOG; ENOG502R1M5; Eukaryota.
DR   HOGENOM; CLU_010748_1_0_1; -.
DR   InParanoid; C4JFE4; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000002058; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Gluconeogenesis; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..714
FT                   /note="Transcription activator of gluconeogenesis
FT                   UREG_00958"
FT                   /id="PRO_0000406455"
FT   DNA_BIND        78..106
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  77213 MW;  A80CD2FE74928992 CRC64;
     MTSNARNGPL PPNPLANSGN NRDISADITM AEQVVRPESQ TQVENSSTKQ PNGQTKPMSA
     SNAKDPLRPR RKKAKRACFA CQRAHLTCGD ERPCQRCIKR GIQNSCHDGV RKKAKYLHDA
     PNEALMPHLQ GQLYTQTNAV RNNMSLTSNG SNSKTNFYPR QNSNFNGYYA TKNDGSLSQS
     QLHDAGRPDT FPSQSPVSPT FSITANSATS GNQNMPSSLP ASNGNASGQA QNGFGSAFFD
     PCDPALFNFD LASMNFGNHY GALEFGMLGH MATGAGDTPP SDSATQHGSV GRNGSGTFAP
     GSNFGESPTA QPSFLFGDPT IAGDWSSSVH TRNIYNQNMN HMSETPHAFA IESGPANFAS
     PNSIESPLLT NSATFDDNTT SAYQNRSSMN PMPPQRQPVV STPQLKHLQL SKRRQRNPSA
     IYESVKEPYS YTTGFHSLTA FIQRRFSTQN TLRIAKALAS IRPSFIATTK TLNRDDLIFM
     EKCFQRTLWE YEDFINACGT PTIVCRRTGE IAAVGKEFSI LTGWRKEVLL GKEPNLNINT
     GGSSGSTSGT SSRGSFTPRA GMEVNPSGRT QPVFLAELLD DESVVEFYED FAKLAFGDSR
     GSVMTTCKLL KYKTKADTDM LPGNTGGTGG GDGQSAASGN GHVKVENGMA ASNGQAQPLS
     QPQRRWSRGG IAGEAGMNQL GFKDGKVECS YCWTVKRDVF DIPMLIVMNF LPCI