ID   DDPS3_ARATH             Reviewed;         302 AA.
AC   Q8RX73; Q9LUY3;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Dehydrodolichyl diphosphate synthase 3;
DE            Short=Dedol-PP synthase 3;
DE            EC=2.5.1.-;
GN   OrderedLocusNames=At5g58780; ORFNames=MZN1.22;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Catalyzes cis-prenyl chain elongation to produce the
CC       polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for
CC       the biosynthesis of several classes of glycoprotein. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SIMILARITY: Belongs to the UPP synthase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA97346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB020755; BAA97346.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED97097.1; -; Genomic_DNA.
DR   EMBL; AY090344; AAL91250.1; -; mRNA.
DR   EMBL; BT004518; AAO42764.1; -; mRNA.
DR   RefSeq; NP_568882.1; NM_125265.3.
DR   AlphaFoldDB; Q8RX73; -.
DR   SMR; Q8RX73; -.
DR   STRING; 3702.AT5G58780.1; -.
DR   PaxDb; Q8RX73; -.
DR   PRIDE; Q8RX73; -.
DR   ProteomicsDB; 224604; -.
DR   EnsemblPlants; AT5G58780.1; AT5G58780.1; AT5G58780.
DR   GeneID; 835992; -.
DR   Gramene; AT5G58780.1; AT5G58780.1; AT5G58780.
DR   KEGG; ath:AT5G58780; -.
DR   Araport; AT5G58780; -.
DR   TAIR; locus:2178838; AT5G58780.
DR   eggNOG; KOG1602; Eukaryota.
DR   HOGENOM; CLU_038505_1_0_1; -.
DR   InParanoid; Q8RX73; -.
DR   OMA; MEHALTH; -.
DR   OrthoDB; 1362420at2759; -.
DR   PhylomeDB; Q8RX73; -.
DR   BioCyc; ARA:AT5G58780-MON; -.
DR   UniPathway; UPA00378; -.
DR   PRO; PR:Q8RX73; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8RX73; baseline and differential.
DR   Genevisible; Q8RX73; AT.
DR   GO; GO:0009570; C:chloroplast stroma; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR   GO; GO:0045547; F:dehydrodolichyl diphosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0002094; F:polyprenyltransferase activity; IDA:TAIR.
DR   GO; GO:0050267; F:rubber cis-polyprenylcistransferase activity; IGI:TAIR.
DR   GO; GO:0009668; P:plastid membrane organization; IBA:GO_Central.
DR   GO; GO:0016094; P:polyprenol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009409; P:response to cold; IEP:TAIR.
DR   CDD; cd00475; Cis_IPPS; 1.
DR   Gene3D; 3.40.1180.10; -; 1.
DR   HAMAP; MF_01139; ISPT; 1.
DR   InterPro; IPR001441; UPP_synth-like.
DR   InterPro; IPR018520; UPP_synth-like_CS.
DR   InterPro; IPR036424; UPP_synth-like_sf.
DR   PANTHER; PTHR10291; PTHR10291; 1.
DR   Pfam; PF01255; Prenyltransf; 1.
DR   SUPFAM; SSF64005; SSF64005; 1.
DR   TIGRFAMs; TIGR00055; uppS; 1.
DR   PROSITE; PS01066; UPP_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Transferase.
FT   CHAIN           1..302
FT                   /note="Dehydrodolichyl diphosphate synthase 3"
FT                   /id="PRO_0000123753"
SQ   SEQUENCE   302 AA;  35195 MW;  E99370F7F0867BBF CRC64;
     MLSILSSLLS LLFLFIISCF FITSHFWFPL SLPKILGFIK ITSSRDDYDN EQRDEGTYVV
     GVEELQRELM PRHVAVIMDG NRRWAKRAGL LTSQGHEAGA KRLIEFSELC FKLGIHTVSA
     FAFSTENWGR HKIEVKCLMS LIQHYLKSKI QYFQREETRV SVIGNLTKIP ESLLRTVQEI
     EEATRSYKKK HLILAIDYSG RLDILRACKS IVKKSEKGLI REEDVDEALI ERELLTNCTE
     FPSPDLLIRT SGEQRISNFF LWQLAYTELF FSPVLWPDFD KDKLLEALVS YQRRERRFGC
     RV