DDPS5_ARATH
ID DDPS5_ARATH Reviewed; 302 AA.
AC Q570Q8; Q9LUY1;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Dehydrodolichyl diphosphate synthase 5;
DE Short=Dedol-PP synthase 5;
DE EC=2.5.1.-;
GN OrderedLocusNames=At5g58784; ORFNames=MZN1.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-302.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cis-prenyl chain elongation to produce the
CC polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for
CC the biosynthesis of several classes of glycoprotein. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPP synthase family. {ECO:0000305}.
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DR EMBL; AB020755; BAA97348.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97099.1; -; Genomic_DNA.
DR EMBL; AK220649; BAD95141.1; -; mRNA.
DR RefSeq; NP_568884.4; NM_125267.5.
DR AlphaFoldDB; Q570Q8; -.
DR SMR; Q570Q8; -.
DR STRING; 3702.AT5G58784.1; -.
DR PaxDb; Q570Q8; -.
DR PRIDE; Q570Q8; -.
DR ProteomicsDB; 224588; -.
DR EnsemblPlants; AT5G58784.1; AT5G58784.1; AT5G58784.
DR GeneID; 835994; -.
DR Gramene; AT5G58784.1; AT5G58784.1; AT5G58784.
DR KEGG; ath:AT5G58784; -.
DR Araport; AT5G58784; -.
DR TAIR; locus:505006702; AT5G58784.
DR eggNOG; KOG1602; Eukaryota.
DR HOGENOM; CLU_038505_1_0_1; -.
DR InParanoid; Q570Q8; -.
DR OMA; RRWAQKR; -.
DR OrthoDB; 1362420at2759; -.
DR PhylomeDB; Q570Q8; -.
DR BioCyc; ARA:AT5G58784-MON; -.
DR UniPathway; UPA00378; -.
DR PRO; PR:Q570Q8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q570Q8; baseline and differential.
DR Genevisible; Q570Q8; AT.
DR GO; GO:0009570; C:chloroplast stroma; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045547; F:dehydrodolichyl diphosphate synthase activity; IBA:GO_Central.
DR GO; GO:0002094; F:polyprenyltransferase activity; IBA:GO_Central.
DR GO; GO:0009668; P:plastid membrane organization; IBA:GO_Central.
DR GO; GO:0016094; P:polyprenol biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0009409; P:response to cold; IBA:GO_Central.
DR CDD; cd00475; Cis_IPPS; 1.
DR Gene3D; 3.40.1180.10; -; 1.
DR HAMAP; MF_01139; ISPT; 1.
DR InterPro; IPR001441; UPP_synth-like.
DR InterPro; IPR018520; UPP_synth-like_CS.
DR InterPro; IPR036424; UPP_synth-like_sf.
DR PANTHER; PTHR10291; PTHR10291; 1.
DR Pfam; PF01255; Prenyltransf; 1.
DR SUPFAM; SSF64005; SSF64005; 1.
DR TIGRFAMs; TIGR00055; uppS; 1.
DR PROSITE; PS01066; UPP_SYNTHASE; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..302
FT /note="Dehydrodolichyl diphosphate synthase 5"
FT /id="PRO_0000123755"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 302 AA; 34893 MW; C35020DDF4936ABE CRC64;
MLSLFSVVFT FLALFLIPGL FISRRLNVPL SLTNILRFIK IIASKYDDEE ERNEKRGTMG
EKQKRGRNIM PKHVAVILDG NRRWAEKRGL GTSEGHEAGA RRLMENAKDC FAMGTNTISL
FAFSTENWER PEDEVKCLMA LFEKYLASDM PYLRSDKIKI SVIGNRTKLP ESLLGLIEEV
EEATKSYEGK NLIIAIDYSG RYDILQACKS LANKVKDGLI QVEDINEKAM EKELLTKCSE
FPNPDLLIRT SGEQRISNFF LWQSAYTELY FPTVLWPDFG EAEYLEALTW YQQRQRRFGR
RV
