DDPS6_ARATH
ID DDPS6_ARATH Reviewed; 295 AA.
AC Q8S2T1; Q94EZ4; Q9SHL2;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Dehydrodolichyl diphosphate synthase 6;
DE Short=Dedol-PP synthase 6;
DE EC=2.5.1.-;
GN OrderedLocusNames=At2g17570; ORFNames=MJB20.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
CC -!- FUNCTION: Catalyzes cis-prenyl chain elongation to produce the
CC polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for
CC the biosynthesis of several classes of glycoprotein. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SIMILARITY: Belongs to the UPP synthase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK62455.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AAL66925.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC007584; AAD32914.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC06654.1; -; Genomic_DNA.
DR EMBL; AF387010; AAK62455.1; ALT_SEQ; mRNA.
DR EMBL; AY072510; AAL66925.1; ALT_SEQ; mRNA.
DR EMBL; AF499435; AAM19345.1; -; mRNA.
DR EMBL; AY954789; AAX55115.1; -; Genomic_DNA.
DR PIR; G84553; G84553.
DR RefSeq; NP_565420.1; NM_127311.5.
DR AlphaFoldDB; Q8S2T1; -.
DR SMR; Q8S2T1; -.
DR STRING; 3702.AT2G17570.1; -.
DR PaxDb; Q8S2T1; -.
DR PRIDE; Q8S2T1; -.
DR ProteomicsDB; 224610; -.
DR EnsemblPlants; AT2G17570.1; AT2G17570.1; AT2G17570.
DR GeneID; 816264; -.
DR Gramene; AT2G17570.1; AT2G17570.1; AT2G17570.
DR KEGG; ath:AT2G17570; -.
DR Araport; AT2G17570; -.
DR TAIR; locus:2053903; AT2G17570.
DR eggNOG; KOG1602; Eukaryota.
DR HOGENOM; CLU_038505_0_5_1; -.
DR InParanoid; Q8S2T1; -.
DR OMA; ICIAYNS; -.
DR OrthoDB; 1362420at2759; -.
DR PhylomeDB; Q8S2T1; -.
DR BioCyc; ARA:AT2G17570-MON; -.
DR UniPathway; UPA00378; -.
DR PRO; PR:Q8S2T1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S2T1; baseline and differential.
DR Genevisible; Q8S2T1; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0002094; F:polyprenyltransferase activity; IBA:GO_Central.
DR GO; GO:0016094; P:polyprenol biosynthetic process; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd00475; Cis_IPPS; 1.
DR Gene3D; 3.40.1180.10; -; 1.
DR HAMAP; MF_01139; ISPT; 1.
DR InterPro; IPR001441; UPP_synth-like.
DR InterPro; IPR018520; UPP_synth-like_CS.
DR InterPro; IPR036424; UPP_synth-like_sf.
DR PANTHER; PTHR10291; PTHR10291; 1.
DR Pfam; PF01255; Prenyltransf; 1.
DR SUPFAM; SSF64005; SSF64005; 1.
DR TIGRFAMs; TIGR00055; uppS; 1.
DR PROSITE; PS01066; UPP_SYNTHASE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Transferase.
FT CHAIN 1..295
FT /note="Dehydrodolichyl diphosphate synthase 6"
FT /id="PRO_0000123756"
FT CONFLICT 57
FT /note="C -> G (in Ref. 4; AAK62455)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 33628 MW; DC5D2E48056C2324 CRC64;
MAELPGQIRH IGGRMSQLLE QIYGFSRRSL FRVISMGPIP CHIAFIMDGN RRYAKKCGLL
DGSGHKAGFS ALMSMLQYCY ELGIKYVTIY AFSIDNFRRK PEEVESVMDL MLEKIKSLLE
KESIVHQYGI RVYFIGNLAL LNDQVRAAAE KVMKATAKNS RVVLLICIAY NSTDEIVQAV
KKSCINKSDN IEASNYKHED SDSDIEGTDM ENQEKKIQLV DIEENMQMSV APNPDILIRS
SGETRLSNFL LWQTGNTQLC SPAALWPEIG LRHLLWAILN FQRNHSYLEK RKKQL
