ID   DDPS7_ARATH             Reviewed;         271 AA.
AC   Q8LED0; Q9FKJ7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Dehydrodolichyl diphosphate synthase 7;
DE            Short=Dedol-PP synthase 7;
DE            EC=2.5.1.-;
GN   OrderedLocusNames=At5g60500; ORFNames=MUF9.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cis-prenyl chain elongation to produce the
CC       polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for
CC       the biosynthesis of several classes of glycoprotein. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPP synthase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB08233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB011483; BAB08233.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002688; AED97337.1; -; Genomic_DNA.
DR   EMBL; AY085488; AAM62714.1; -; mRNA.
DR   RefSeq; NP_200858.1; NM_125443.1.
DR   AlphaFoldDB; Q8LED0; -.
DR   SMR; Q8LED0; -.
DR   STRING; 3702.AT5G60500.1; -.
DR   PaxDb; Q8LED0; -.
DR   PRIDE; Q8LED0; -.
DR   ProteomicsDB; 224605; -.
DR   EnsemblPlants; AT5G60500.1; AT5G60500.1; AT5G60500.
DR   GeneID; 836171; -.
DR   Gramene; AT5G60500.1; AT5G60500.1; AT5G60500.
DR   KEGG; ath:AT5G60500; -.
DR   Araport; AT5G60500; -.
DR   TAIR; locus:2175168; AT5G60500.
DR   eggNOG; KOG1602; Eukaryota.
DR   HOGENOM; CLU_038505_0_5_1; -.
DR   InParanoid; Q8LED0; -.
DR   OMA; DESTHIF; -.
DR   OrthoDB; 1362420at2759; -.
DR   PhylomeDB; Q8LED0; -.
DR   BioCyc; ARA:AT5G60500-MON; -.
DR   UniPathway; UPA00378; -.
DR   PRO; PR:Q8LED0; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8LED0; baseline and differential.
DR   Genevisible; Q8LED0; AT.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0002094; F:polyprenyltransferase activity; IBA:GO_Central.
DR   GO; GO:0016094; P:polyprenol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00475; Cis_IPPS; 1.
DR   Gene3D; 3.40.1180.10; -; 1.
DR   InterPro; IPR001441; UPP_synth-like.
DR   InterPro; IPR018520; UPP_synth-like_CS.
DR   InterPro; IPR036424; UPP_synth-like_sf.
DR   PANTHER; PTHR10291; PTHR10291; 1.
DR   Pfam; PF01255; Prenyltransf; 1.
DR   SUPFAM; SSF64005; SSF64005; 1.
DR   TIGRFAMs; TIGR00055; uppS; 1.
DR   PROSITE; PS01066; UPP_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..271
FT                   /note="Dehydrodolichyl diphosphate synthase 7"
FT                   /id="PRO_0000123757"
FT   TRANSMEM        24..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  30901 MW;  3324FEC437BE6BEE CRC64;
     MNTLEEVDES THIFNALMSL MRKFLFRVLC VGPIPTNISF IMDGNRRFAK KHNLIGLDAG
     HRAGFISVKY ILQYCKEIGV PYVTLHAFGM DNFKRGPEEV KCVMDLMLEK VELAIDQAVS
     GNMNGVRIIF AGDLDSLNEH FRAATKKLME LTEENRDLIV VVCVAYSTSL EIVHAVRKSC
     VRKCTNGDDL VLLELSDVEE CMYTSIVPVP DLVIRTGGGD RLSNFMTWQT SRSLLHRTEA
     LWPELGLWHL VWAILKFQRM QDYLTKKKKL D