DDR4_ARATH
ID DDR4_ARATH Reviewed; 750 AA.
AC F4IDY7; Q9LMD2; Q9LMD3;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=DDT domain-containing protein DDR4 {ECO:0000305};
DE AltName: Full=DDT-related protein 4 {ECO:0000303|PubMed:23691993};
GN Name=DDR4 {ECO:0000303|PubMed:23691993};
GN OrderedLocusNames=At1g18950 {ECO:0000312|Araport:AT1G18950};
GN ORFNames=F14D16.9/F14D16.10 {ECO:0000312|EMBL:AAF79283.1,
GN ECO:0000312|EMBL:AAF79284.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH CHR11.
RX PubMed=23691993; DOI=10.1111/jipb.12069;
RA Dong J., Gao Z., Liu S., Li G., Yang Z., Huang H., Xu L.;
RT "SLIDE, the protein interacting domain of Imitation Switch remodelers,
RT binds DDT-domain proteins of different subfamilies in chromatin remodeling
RT complexes.";
RL J. Integr. Plant Biol. 55:928-937(2013).
CC -!- FUNCTION: Probable transcription regulator.
CC {ECO:0000305|PubMed:23691993}.
CC -!- SUBUNIT: Interacts (via the DDT domain) with CHR11 (via C-terminus).
CC {ECO:0000269|PubMed:23691993}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79283.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes.; Evidence={ECO:0000305};
CC Sequence=AAF79284.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC068602; AAF79283.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC068602; AAF79284.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29783.1; -; Genomic_DNA.
DR PIR; D86323; D86323.
DR RefSeq; NP_173329.2; NM_101752.4.
DR AlphaFoldDB; F4IDY7; -.
DR STRING; 3702.AT1G18950.1; -.
DR iPTMnet; F4IDY7; -.
DR PaxDb; F4IDY7; -.
DR PRIDE; F4IDY7; -.
DR EnsemblPlants; AT1G18950.1; AT1G18950.1; AT1G18950.
DR GeneID; 838476; -.
DR Gramene; AT1G18950.1; AT1G18950.1; AT1G18950.
DR KEGG; ath:AT1G18950; -.
DR Araport; AT1G18950; -.
DR TAIR; locus:2011261; AT1G18950.
DR eggNOG; ENOG502QUDP; Eukaryota.
DR HOGENOM; CLU_022510_0_0_1; -.
DR InParanoid; F4IDY7; -.
DR OMA; QRINYQQ; -.
DR PRO; PR:F4IDY7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IDY7; baseline and differential.
DR GO; GO:0031010; C:ISWI-type complex; IDA:TAIR.
DR GO; GO:0031213; C:RSF complex; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028938; Rsf1-like.
DR PANTHER; PTHR14296; PTHR14296; 1.
DR Pfam; PF02791; DDT; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..750
FT /note="DDT domain-containing protein DDR4"
FT /id="PRO_0000435122"
FT DOMAIN 133..192
FT /note="DDT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..99
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..581
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 750 AA; 86250 MW; 24B990421C6D209B CRC64;
MGSSSDIVPD RSPADDVAPV TDTKIPKEEP LTLRRTRPSR ACTVRAQQRL QELQAAERKL
KPPKKEYKRE QHRRREEVVE EDEDSEDDDQ EDEENDGDDE SNPKQCVAGG SSTKIITSLV
PPPEPSQMPR WNLRSMWELA SVLNFLHVFR PLLKINAEFS AEEFETALLT PNDTLSDIHI
PLLKAIPPVT RMALTRDTWV TVLCRKIRDC WHWVAEGDLP IVALQGREIE VYKNLDPAIR
VVILKALCDI RVEQEDIRSY IDNSLKTGVH LSVFRKDRVG GDSHGVNFWY EEDPLIGHRL
YREIRKAEVL KVKTKGSKIL PNITYQWETV ATNFDEFQDV SEKLLQSSSR IEVSLGKKLV
KDMLPEIEKE HKRKEKLLKK QHRQALLLDN FVVVDGLAGR SLRDRKPVRY TFDDYDKSIN
DAIKITKKKH PSPEHPLHRR ESARLDALAN GRSTSSTHPT EPVNDTASGR SSDFADYDDF
DEHRDESLDR RRRQRPQRYS ATDFVETVSD NEVEFQSDDD IYGEAVYDEE YLKKRKQKKL
SSGSEGDEEK GDEEYKWDED NAEYEEEEEE EEEEDSLSAS EEDSDEPRRA KKMPRRETKL
RSRSNDFRPG LRRSKRATRI DYQQYEFSDS DKEATGLAKR KRFVEPDEPS DETGNGDFTM
GSQDSEENAN DPETKSGEEE EPRDVNDNAD TTNGKENNQL NKSNGTTDQE EVEGVVGKRR
YLDLNELAPV SGFDDGPSTV LKDDDKTDNS
