ID   DDRC_DEIRA              Reviewed;         291 AA.
AC   Q9RYE6;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=DNA damage response protein C;
GN   Name=ddrC; OrderedLocusNames=DR_0003;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
RN   [2]
RP   INDUCTION, ROLE IN RADIORESISTANCE, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=15454524; DOI=10.1534/genetics.104.029249;
RA   Tanaka M., Earl A.M., Howell H.A., Park M.J., Eisen J.A., Peterson S.N.,
RA   Battista J.R.;
RT   "Analysis of Deinococcus radiodurans's transcriptional response to ionizing
RT   radiation and desiccation reveals novel proteins that contribute to extreme
RT   radioresistance.";
RL   Genetics 168:21-33(2004).
CC   -!- FUNCTION: Appears to contribute to D.radiodurans capacity to survive
CC       exposure to ionizing radiation. May play a role in DNA repair and
CC       genome reconstitution. {ECO:0000269|PubMed:15454524}.
CC   -!- INDUCTION: Induced to high levels following extreme ionizing radiation
CC       exposure. Also highly induced in response to desiccation stress.
CC       {ECO:0000269|PubMed:15454524}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene show a normal growth
CC       rate, do not exhibit a decrease in the efficiency of natural
CC       transformation, and is as resistant to ionizing radiation as wild-type.
CC       However, deletion of the ddrC gene decreases the ionizing radiation
CC       resistance of the ddrB mutant strain or the recA mutant strain, and
CC       appears to increase that of the pprA mutant strain. Moreover, cells
CC       lacking both ddrC and ddrD exhibit a slight (two-fold) increase in
CC       sensitivity to ionizing radiation, but this phenotype is apparent only
CC       at the highest applied doses. {ECO:0000269|PubMed:15454524}.
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DR   EMBL; AE000513; AAF09602.1; -; Genomic_DNA.
DR   PIR; F75571; F75571.
DR   RefSeq; NP_293729.1; NC_001263.1.
DR   AlphaFoldDB; Q9RYE6; -.
DR   STRING; 243230.DR_0003; -.
DR   EnsemblBacteria; AAF09602; AAF09602; DR_0003.
DR   KEGG; dra:DR_0003; -.
DR   HOGENOM; CLU_955529_0_0_0; -.
DR   OMA; HAYILAY; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0071465; P:cellular response to desiccation; IEP:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEP:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Reference proteome; Stress response.
FT   CHAIN           1..291
FT                   /note="DNA damage response protein C"
FT                   /id="PRO_0000394493"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  29786 MW;  FCC08764ABA2DC69 CRC64;
     MGTGDPSPLA SQGPLPLVEG QKMKKPPPVR RGMNEAMEDR GSFFMALVSA YALHLARPFP
     ALALAAGYLF VEGEDGCVAP RFAFLNGAGG HGVDVGQPQQ FGARQAVAGG LDAAFLTYRR
     AVLAKDGAVA DAAELTVDPA LATVPGDGGE QFAPGASAFQ SGSEPAPGVR LGVALGNLGS
     HAHVALHGAG EQLPRPLLPA PGFGGVEGEG KRHEIGHAHG GLGSGAEVAV RLGQAVFDQR
     RFPALGEPEL LLGGGGVKQT VRADRQPHGA EIEGQRSVLH TDILAQIMFL T