ID   DDRD_DEIRA              Reviewed;         198 AA.
AC   Q9RXI7;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=DNA damage response protein D;
GN   Name=ddrD; OrderedLocusNames=DR_0326;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
RN   [2]
RP   INDUCTION, ROLE IN RADIORESISTANCE, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=15454524; DOI=10.1534/genetics.104.029249;
RA   Tanaka M., Earl A.M., Howell H.A., Park M.J., Eisen J.A., Peterson S.N.,
RA   Battista J.R.;
RT   "Analysis of Deinococcus radiodurans's transcriptional response to ionizing
RT   radiation and desiccation reveals novel proteins that contribute to extreme
RT   radioresistance.";
RL   Genetics 168:21-33(2004).
CC   -!- FUNCTION: Appears to contribute to D.radiodurans capacity to survive
CC       exposure to ionizing radiation. May play a role in DNA repair and
CC       genome reconstitution. {ECO:0000269|PubMed:15454524}.
CC   -!- INDUCTION: Induced to high levels following extreme ionizing radiation
CC       exposure. Also highly induced in response to desiccation stress.
CC       {ECO:0000269|PubMed:15454524}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene show a normal growth
CC       rate, do not exhibit a decrease in the efficiency of natural
CC       transformation, and is as resistant to ionizing radiation as wild-type.
CC       However, deletion of the ddrC gene decreases the ionizing radiation
CC       resistance of the recA mutant strain, and appears to increase that of
CC       the pprA mutant strain. Moreover, cells lacking both ddrC and ddrD
CC       exhibit a slight (two-fold) increase in sensitivity to ionizing
CC       radiation, but this phenotype is apparent only at the highest applied
CC       doses. {ECO:0000269|PubMed:15454524}.
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DR   EMBL; AE000513; AAF09913.1; -; Genomic_DNA.
DR   PIR; C75532; C75532.
DR   RefSeq; NP_294049.1; NC_001263.1.
DR   RefSeq; WP_010886971.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RXI7; -.
DR   STRING; 243230.DR_0326; -.
DR   EnsemblBacteria; AAF09913; AAF09913; DR_0326.
DR   KEGG; dra:DR_0326; -.
DR   PATRIC; fig|243230.17.peg.492; -.
DR   HOGENOM; CLU_1583810_0_0_0; -.
DR   OMA; HEAPEYA; -.
DR   OrthoDB; 1692324at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0071465; P:cellular response to desiccation; IEP:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEP:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Reference proteome; Stress response.
FT   CHAIN           1..198
FT                   /note="DNA damage response protein D"
FT                   /id="PRO_0000394494"
FT   REGION          124..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  21157 MW;  B4F552D2D95E7211 CRC64;
     MDTLKKAGTM LAHLDLFHSM LDLRRLLQLA AYMKERGDRA MLISAGEITL IGSESMTAPE
     VVTSKGETID AATAYRVLGQ LEGYEAPEYA VNREALAALN ARAVAELEGS EALRAFGDTL
     ARISAAPTDP AGPERPGTDR AERTAAERTA SERATHDRAS TERPARPRRS AEPEAVRTED
     APQPNAEASE AGENTPAA