ID   DDRGK_BRAFL             Reviewed;         298 AA.
AC   C3Y431;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=DDRGK domain-containing protein 1 {ECO:0000305};
DE   Flags: Precursor;
GN   ORFNames=BRAFLDRAFT_114851 {ECO:0000312|EMBL:EEN65057.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82; TISSUE=Testis;
RX   PubMed=18563158; DOI=10.1038/nature06967;
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- FUNCTION: May play a role in protein ufmylation and regulate different
CC       cellular process. {ECO:0000250|UniProtKB:Q80WW9,
CC       ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; GG666484; EEN65057.1; -; Genomic_DNA.
DR   RefSeq; XP_002609047.1; XM_002609001.1.
DR   AlphaFoldDB; C3Y431; -.
DR   SMR; C3Y431; -.
DR   STRING; 7739.XP_002609047.1; -.
DR   eggNOG; KOG3054; Eukaryota.
DR   InParanoid; C3Y431; -.
DR   OMA; QEFIQYI; -.
DR   OrthoDB; 1553559at2759; -.
DR   Proteomes; UP000001554; Partially assembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Reference proteome; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..298
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391854"
FT   REGION          28..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  34270 MW;  AAD02BB7DBA44E57 CRC64;
     MVEPAVLYAV AAVFVAVLLF LAVKLRGGQE QQPADDGQRR GAPRPRTDAE RAAGAPRRVR
     GARQRLQAAR RINQQDSEGD SDSDEGRPEI DIPEGMKVGA KKMKKLEMKA EKKAAREAAE
     QEREERKQRE KMLEEKRKQE EEEEKLEEER RAEEERKAKE EKAAREHEEY LMMKEAFTVE
     EEGHEEILDE DATENLLQDF IDHIKAVKVV LLEDLAAQFN MRTQDCIQRV QELREQGRLT
     GVIDDRGKFI YISQEELQAV AKFIKQRGRV SITDLVESSN QLIHLIPDTE QVIRVQSS