ID   DDRGK_DROGR             Reviewed;         303 AA.
AC   B4JG35;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=DDRGK domain-containing protein 1;
DE   Flags: Precursor;
GN   ORFNames=GH19408;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC       the ubiquitin-like modifier UFM1 to substrate proteins.
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; CH916369; EDV93602.1; -; Genomic_DNA.
DR   RefSeq; XP_001990540.1; XM_001990504.1.
DR   AlphaFoldDB; B4JG35; -.
DR   SMR; B4JG35; -.
DR   STRING; 7222.FBpp0153314; -.
DR   EnsemblMetazoa; FBtr0154822; FBpp0153314; FBgn0126873.
DR   GeneID; 6563510; -.
DR   KEGG; dgr:6563510; -.
DR   eggNOG; KOG3054; Eukaryota.
DR   HOGENOM; CLU_059562_1_0_1; -.
DR   InParanoid; B4JG35; -.
DR   OMA; QEFIQYI; -.
DR   OrthoDB; 1446840at2759; -.
DR   PhylomeDB; B4JG35; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Ubl conjugation pathway.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..303
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391859"
FT   REGION          31..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   303 AA;  33956 MW;  B0331724033660D1 CRC64;
     MDLILLIGIA TALLIILLTL YFLQKRNAPA ETKAAAQPQR GVPLRAQEGV PRRAQIARNQ
     RNRLRANQNA PDAVAPVAAA PAAAIDPDGD EDGDENGPRV PQGAVLDEKM GAKKRAKMEA
     KEQKRLQREQ ELHDREQRKV KEAKEEAERK QQDDLDAEVE RKRVEAERVV KELHERKEHE
     MYLKMKATFS VEEEGFEEDD ADDKEADFIQ YIKDNKVVLL EDLATTFKLK TQQAIERIQE
     LQAEDTITGV IDDRGKFIYV SEAELAAVAK FIKQRGRVSI ADLAESSNNL INLTPVTASE
     GGA