DDRGK_DROME
ID DDRGK_DROME Reviewed; 309 AA.
AC Q9VDD1;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=DDRGK domain-containing protein 1;
DE Flags: Precursor;
GN ORFNames=CG5862;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC the ubiquitin-like modifier UFM1 to substrate proteins.
CC {ECO:0000250|UniProtKB:Q96HY6}.
CC -!- INTERACTION:
CC Q9VDD1; Q9VI55: Ufl1; NbExp=4; IntAct=EBI-148976, EBI-172922;
CC -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55865.1; -; Genomic_DNA.
DR EMBL; AY060740; AAL28288.1; -; mRNA.
DR RefSeq; NP_650954.1; NM_142697.4.
DR AlphaFoldDB; Q9VDD1; -.
DR SMR; Q9VDD1; -.
DR BioGRID; 67486; 3.
DR IntAct; Q9VDD1; 5.
DR STRING; 7227.FBpp0083451; -.
DR PaxDb; Q9VDD1; -.
DR PRIDE; Q9VDD1; -.
DR DNASU; 42516; -.
DR EnsemblMetazoa; FBtr0084049; FBpp0083451; FBgn0038868.
DR GeneID; 42516; -.
DR KEGG; dme:Dmel_CG5862; -.
DR UCSC; CG5862-RA; d. melanogaster.
DR FlyBase; FBgn0038868; CG5862.
DR VEuPathDB; VectorBase:FBgn0038868; -.
DR eggNOG; KOG3054; Eukaryota.
DR GeneTree; ENSGT00390000017193; -.
DR HOGENOM; CLU_059562_1_0_1; -.
DR InParanoid; Q9VDD1; -.
DR OMA; QEFIQYI; -.
DR OrthoDB; 1446840at2759; -.
DR PhylomeDB; Q9VDD1; -.
DR BioGRID-ORCS; 42516; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42516; -.
DR PRO; PR:Q9VDD1; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038868; Expressed in male reproductive gland and 12 other tissues.
DR Genevisible; Q9VDD1; DM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:FlyBase.
DR GO; GO:0044389; F:ubiquitin-like protein ligase binding; ISS:FlyBase.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:FlyBase.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR019153; DDRGK_dom-contain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09756; DDRGK; 1.
DR SMART; SM01128; DDRGK; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Signal; Ubl conjugation pathway.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..309
FT /note="DDRGK domain-containing protein 1"
FT /id="PRO_0000391860"
FT REGION 32..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 34332 MW; 7B22B64909999105 CRC64;
MDLIILVGIA VALLVVIVTL YLLQKKNAAP ETKVAAAPQR GVPQRAQEGV PRRAQIARNQ
RNRLRQNVPA APVAAAAGAL PAAGDSDHED EGQVDGDEAR VPQGAVLDEK MGAKKRAKME
AKEQKRLQRE QELHDREQRK VKEAKEEAER KQQEDLEAEA ERKRVDAERL AKEERERKEH
EEYLKMKAAF SVEEEGFEEG DADDQDNLLA DFIQYIRDNK VVVLEDLAVA FKLKTQQVID
RIQNLQADGT LTGVIDDRGK FIYVSEKELL AVAKFIKQRG RVSIAELAES SNNLINLTPI
SAGGGEASS
