ID   DDRGK_DROPS             Reviewed;         309 AA.
AC   Q295B1;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DDRGK domain-containing protein 1;
DE   Flags: Precursor;
GN   ORFNames=GA19186;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC       the ubiquitin-like modifier UFM1 to substrate proteins.
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; CM000070; EAL28801.1; -; Genomic_DNA.
DR   RefSeq; XP_001359651.1; XM_001359614.4.
DR   AlphaFoldDB; Q295B1; -.
DR   SMR; Q295B1; -.
DR   STRING; 7237.FBpp0284661; -.
DR   EnsemblMetazoa; FBtr0286223; FBpp0284661; FBgn0079183.
DR   GeneID; 4802807; -.
DR   KEGG; dpo:Dpse_GA19186; -.
DR   eggNOG; KOG3054; Eukaryota.
DR   HOGENOM; CLU_059562_1_0_1; -.
DR   InParanoid; Q295B1; -.
DR   OMA; QEFIQYI; -.
DR   PhylomeDB; Q295B1; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0079183; Expressed in male reproductive system and 3 other tissues.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Ubl conjugation pathway.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..309
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391863"
FT   REGION          30..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  34369 MW;  FC2D395D5E975A1E CRC64;
     MDLIILVGIA SALLVVILTI FFLQKKKGGT EAKEAAAPPQ RGVPLRAQEG VPRRAQIARN
     QRNRLRQNAP AAAPAAAAAL QAADAEGDND DENPDGDGQR MPQGAVLDEK MGAKKRAKME
     AKEQKRLHRE QELIDREQRK VKEAKEEAER KQQEDFQEEA DRKRAEAERL VKEERERKEH
     EEYLKMKAGF SVEEEGFEEG DADDQDNLLA DFIQYIKDNK VVLLEDLAVA FKLKTQQAIE
     RIQDLQANGT LTGVIDDRGK FIYVSEEELA AVAKFIKQRG RVSIVELAES SNNLINLTPV
     SAGAGEGSS