ID   DDRGK_DROWI             Reviewed;         307 AA.
AC   B4NKL1;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=DDRGK domain-containing protein 1;
DE   Flags: Precursor;
GN   ORFNames=GK14514;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC       the ubiquitin-like modifier UFM1 to substrate proteins.
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; CH964272; EDW85183.1; -; Genomic_DNA.
DR   RefSeq; XP_002074197.1; XM_002074161.2.
DR   AlphaFoldDB; B4NKL1; -.
DR   SMR; B4NKL1; -.
DR   STRING; 7260.FBpp0243657; -.
DR   EnsemblMetazoa; FBtr0245165; FBpp0243657; FBgn0216520.
DR   GeneID; 6651052; -.
DR   KEGG; dwi:6651052; -.
DR   eggNOG; KOG3054; Eukaryota.
DR   HOGENOM; CLU_059562_1_0_1; -.
DR   InParanoid; B4NKL1; -.
DR   OMA; QEFIQYI; -.
DR   OrthoDB; 1446840at2759; -.
DR   PhylomeDB; B4NKL1; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Ubl conjugation pathway.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..307
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391866"
FT   REGION          32..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34054 MW;  1DD38DCA6FB046B2 CRC64;
     MDLILLVGIA VALLVILATL YFLQNKNKAA GEAKPAAAAP RRGVPQRAQE GVPRRAQIAR
     NQRNRLQQNA PAPAPEAVAP AAAGDSDDDE ENVGADGARL PQGAVLNEKM GAKKRAKMEA
     KEQKRLQREH ELQEREKRKV KEAKEDAERK QQEEVEAEAE RKKLDAERLA KEERERKEHE
     EYLKMKAAFN VEEEGFEEGD ADDQESLLAD FIQYIKDNKV VLLEDLAVAF KLKTQQAIER
     IQELQANGSL TGVIDDRGKF IYISQEELAA VAKFIKQRGR VSIAELAESS NNLINLTPVQ
     SAAGGDS