ID   DDRGK_DROYA             Reviewed;         312 AA.
AC   B4PQC4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=DDRGK domain-containing protein 1;
DE   Flags: Precursor;
GN   ORFNames=GE25716;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC       the ubiquitin-like modifier UFM1 to substrate proteins.
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; CM000160; EDW96233.1; -; Genomic_DNA.
DR   RefSeq; XP_002096521.1; XM_002096485.2.
DR   AlphaFoldDB; B4PQC4; -.
DR   SMR; B4PQC4; -.
DR   STRING; 7245.FBpp0270726; -.
DR   EnsemblMetazoa; FBtr0272234; FBpp0270726; FBgn0242774.
DR   GeneID; 6535905; -.
DR   KEGG; dya:Dyak_GE25716; -.
DR   eggNOG; KOG3054; Eukaryota.
DR   HOGENOM; CLU_059562_1_0_1; -.
DR   OMA; HIAMESK; -.
DR   OrthoDB; 1446840at2759; -.
DR   PhylomeDB; B4PQC4; -.
DR   Proteomes; UP000002282; Chromosome 3R.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Signal; Ubl conjugation pathway.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..312
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391867"
FT   REGION          59..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34811 MW;  C40AE323C3CD341C CRC64;
     MELIILVGIA TALLVVIITL YLLQKKNAAP ETKPAAALQR GVPQRVQEGV PRRAQIARNQ
     RNRLRQNAPA APAGQVAPAA GPPAAPGDSD HENEGQVDDD DARVPQGAVL DEKMGAKKRA
     KMEAKEQKRL QREQELHDRE QRKVKEAKEE AERKHQEDLE AEVERKRVEA ERLAKEERER
     KEHEEYLKMK AAFSVEEEGF EEGDADEQDS LLADFIQYIR DNKVVVLEDL AVAFKLKTQQ
     VIDRIQELQA DGTLTGVIDD RGKFIYVSEE ELSAVAKFIK QRGRVSIAEL AESSNNLINL
     TPISAGGEEA SS