ID   DDRGK_OSMMO             Reviewed;         298 AA.
AC   C1BL82;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=DDRGK domain-containing protein 1 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=ddrgk1 {ECO:0000250|UniProtKB:Q96HY6};
OS   Osmerus mordax (Rainbow smelt) (Atherina mordax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Stomiati; Osmeriformes; Osmeridae;
OC   Osmerus.
OX   NCBI_TaxID=8014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RA   von Schalburg K., Leong J., Cooper G., Davidson W.S., Koop B.F.;
RT   "Osmerus mordax full-length cDNAs.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate adapter for ufmylation, the covalent attachment of
CC       the ubiquitin-like modifier UFM1 to substrate proteins, which plays a
CC       key role in reticulophagy (also called ER-phagy). In response to
CC       endoplasmic reticulum stress, promotes recruitment of the E3 ufm1-
CC       protein ligase ufl1 to the endoplasmic reticulum membrane, leading to
CC       ufmylation of target proteins and subsequent reticulophagy of
CC       endoplasmic reticulum sheets (By similarity). Plays a role in cartilage
CC       development through sox9, inhibiting the ubiquitin-mediated proteasomal
CC       degradation of this transcriptional regulator (By similarity).
CC       {ECO:0000250|UniProtKB:Q6P0E5, ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q96HY6}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q96HY6}. Note=Localizes to the endoplasmic
CC       reticulum membrane in response to endoplasmic reticulum stress.
CC       {ECO:0000250|UniProtKB:Q96HY6}.
CC   -!- SIMILARITY: Belongs to the DDRGK1 family. {ECO:0000305}.
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DR   EMBL; BT075361; ACO09785.1; -; mRNA.
DR   AlphaFoldDB; C1BL82; -.
DR   SMR; C1BL82; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:1903895; P:negative regulation of IRE1-mediated unfolded protein response; ISS:UniProtKB.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; ISS:UniProtKB.
DR   GO; GO:0070972; P:protein localization to endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0071569; P:protein ufmylation; ISS:UniProtKB.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISS:UniProtKB.
DR   GO; GO:0061709; P:reticulophagy; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR019153; DDRGK_dom-contain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF09756; DDRGK; 1.
DR   SMART; SM01128; DDRGK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Signal; Ubl conjugation pathway.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..298
FT                   /note="DDRGK domain-containing protein 1"
FT                   /id="PRO_0000391853"
FT   DOMAIN          215..259
FT                   /note="PCI"
FT   REGION          71..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  34644 MW;  2759B7281F115D4C CRC64;
     MDIVLYFVAV PILIVLIVSA VKVRGKTEED NHEARQEVAA QVVGRLQAEE GSNRLRRRRN
     LNRMMANRMA NSAYREAADN DSPVEVEEEY EEAEQQSQAT GKRGAKKQKK LEEKQAKRAQ
     REAELEEREE RKRTQELREE ERRKEDKKER ILEQRQEEEE LRAKEEQEKR EEEEYLCLKQ
     SFVVEEQGEA DELTEQESQN LLQEFIQHIK DCKVVLLEDL ASHFGLRTQD AISRLQDLLS
     DGSITGVIDD RGKFIFITPE EMNVVAQFIR QRGRVSITDL AQASNSLINL IPEIHNTA