DDT4L_HUMAN
ID DDT4L_HUMAN Reviewed; 193 AA.
AC Q96D03; B2R7C3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=DNA damage-inducible transcript 4-like protein;
DE AltName: Full=HIF-1 responsive protein RTP801-like;
DE AltName: Full=Protein regulated in development and DNA damage response 2;
DE Short=REDD-2;
GN Name=DDIT4L; Synonyms=REDD2, RTP801L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=12453409; DOI=10.1016/s1097-2765(02)00706-2;
RA Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K.,
RA Oliner J.D., McKeon F., Haber D.A.;
RT "REDD1, a developmentally regulated transcriptional target of p63 and p53,
RT links p63 to regulation of reactive oxygen species.";
RL Mol. Cell 10:995-1005(2002).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=15308555; DOI=10.1161/01.atv.0000142366.69080.c3;
RA Cuaz-Perolin C., Furman C., Larigauderie G., Legedz L., Lasselin C.,
RA Copin C., Jaye M., Searfoss G., Yu K.T., Duverger N., Negre-Salvayre A.,
RA Fruchart J.-C., Rouis M.;
RT "REDD2 gene is upregulated by modified LDL or hypoxia and mediates human
RT macrophage cell death.";
RL Arterioscler. Thromb. Vasc. Biol. 24:1830-1835(2004).
RN [7]
RP FUNCTION.
RX PubMed=15545625; DOI=10.1101/gad.1256804;
RA Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E.,
RA Witters L.A., Ellisen L.W., Kaelin W.G. Jr.;
RT "Regulation of mTOR function in response to hypoxia by REDD1 and the
RT TSC1/TSC2 tumor suppressor complex.";
RL Genes Dev. 18:2893-2904(2004).
RN [8]
RP FUNCTION.
RX PubMed=15632201; DOI=10.1074/jbc.c400557200;
RA Corradetti M.N., Inoki K., Guan K.-L.;
RT "The stress-inducted proteins RTP801 and RTP801L are negative regulators of
RT the mammalian target of rapamycin pathway.";
RL J. Biol. Chem. 280:9769-9772(2005).
CC -!- FUNCTION: Inhibits cell growth by regulating the TOR signaling pathway
CC upstream of the TSC1-TSC2 complex and downstream of AKT1.
CC {ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}.
CC -!- INTERACTION:
CC Q96D03; O95342: ABCB11; NbExp=3; IntAct=EBI-742054, EBI-3914067;
CC Q96D03; Q96HD9: ACY3; NbExp=5; IntAct=EBI-742054, EBI-3916242;
CC Q96D03; Q63HM1: AFMID; NbExp=5; IntAct=EBI-742054, EBI-13286382;
CC Q96D03; Q96BJ3: AIDA; NbExp=3; IntAct=EBI-742054, EBI-4401674;
CC Q96D03; P31749: AKT1; NbExp=3; IntAct=EBI-742054, EBI-296087;
CC Q96D03; Q9NR81: ARHGEF3; NbExp=3; IntAct=EBI-742054, EBI-10312733;
CC Q96D03; Q7Z6K5: ARPIN; NbExp=3; IntAct=EBI-742054, EBI-10258086;
CC Q96D03; O14525-2: ASTN1; NbExp=3; IntAct=EBI-742054, EBI-21977454;
CC Q96D03; O95429: BAG4; NbExp=3; IntAct=EBI-742054, EBI-2949658;
CC Q96D03; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-742054, EBI-11977289;
CC Q96D03; Q9BZR8: BCL2L14; NbExp=3; IntAct=EBI-742054, EBI-1385773;
CC Q96D03; P55957: BID; NbExp=3; IntAct=EBI-742054, EBI-519672;
CC Q96D03; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-742054, EBI-725606;
CC Q96D03; Q96B23: C18orf25; NbExp=3; IntAct=EBI-742054, EBI-742108;
CC Q96D03; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-742054, EBI-741214;
CC Q96D03; Q49AR2: C5orf22; NbExp=3; IntAct=EBI-742054, EBI-746224;
CC Q96D03; Q9NP86: CABP5; NbExp=3; IntAct=EBI-742054, EBI-10311131;
CC Q96D03; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-742054, EBI-739580;
CC Q96D03; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-742054, EBI-11530605;
CC Q96D03; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-742054, EBI-10258233;
CC Q96D03; P51946: CCNH; NbExp=3; IntAct=EBI-742054, EBI-741406;
CC Q96D03; O75909-2: CCNK; NbExp=3; IntAct=EBI-742054, EBI-12010594;
CC Q96D03; P32320: CDA; NbExp=5; IntAct=EBI-742054, EBI-9250559;
CC Q96D03; O75419: CDC45; NbExp=3; IntAct=EBI-742054, EBI-374969;
CC Q96D03; P55273: CDKN2D; NbExp=3; IntAct=EBI-742054, EBI-745859;
CC Q96D03; Q6NVV7: CDPF1; NbExp=3; IntAct=EBI-742054, EBI-2802782;
CC Q96D03; Q96LK0: CEP19; NbExp=3; IntAct=EBI-742054, EBI-741885;
CC Q96D03; Q9HD42: CHMP1A; NbExp=3; IntAct=EBI-742054, EBI-1057156;
CC Q96D03; O95833: CLIC3; NbExp=3; IntAct=EBI-742054, EBI-10192241;
CC Q96D03; P49760: CLK2; NbExp=3; IntAct=EBI-742054, EBI-750020;
CC Q96D03; P49761: CLK3; NbExp=3; IntAct=EBI-742054, EBI-745579;
CC Q96D03; Q9UBL6-2: CPNE7; NbExp=5; IntAct=EBI-742054, EBI-12012272;
CC Q96D03; Q10570: CPSF1; NbExp=3; IntAct=EBI-742054, EBI-347859;
CC Q96D03; Q8IUI8: CRLF3; NbExp=3; IntAct=EBI-742054, EBI-2872414;
CC Q96D03; P53674: CRYBB1; NbExp=3; IntAct=EBI-742054, EBI-7519424;
CC Q96D03; P41240: CSK; NbExp=3; IntAct=EBI-742054, EBI-1380630;
CC Q96D03; P78358: CTAG1B; NbExp=3; IntAct=EBI-742054, EBI-1188472;
CC Q96D03; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-742054, EBI-11962928;
CC Q96D03; P07108-2: DBI; NbExp=3; IntAct=EBI-742054, EBI-12847580;
CC Q96D03; Q9H773: DCTPP1; NbExp=3; IntAct=EBI-742054, EBI-723569;
CC Q96D03; Q05D60: DEUP1; NbExp=3; IntAct=EBI-742054, EBI-748597;
CC Q96D03; O43598: DNPH1; NbExp=5; IntAct=EBI-742054, EBI-748674;
CC Q96D03; Q8TEW6: DOK4; NbExp=3; IntAct=EBI-742054, EBI-6918542;
CC Q96D03; Q9BVJ7: DUSP23; NbExp=3; IntAct=EBI-742054, EBI-724940;
CC Q96D03; Q68J44: DUSP29; NbExp=3; IntAct=EBI-742054, EBI-1054321;
CC Q96D03; Q14240-2: EIF4A2; NbExp=3; IntAct=EBI-742054, EBI-10232522;
CC Q96D03; P38919: EIF4A3; NbExp=3; IntAct=EBI-742054, EBI-299104;
CC Q96D03; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-742054, EBI-74090;
CC Q96D03; Q15056-2: EIF4H; NbExp=3; IntAct=EBI-742054, EBI-12222405;
CC Q96D03; Q9Y6C2-2: EMILIN1; NbExp=3; IntAct=EBI-742054, EBI-11748557;
CC Q96D03; Q32P44: EML3; NbExp=3; IntAct=EBI-742054, EBI-1046713;
CC Q96D03; O15197-2: EPHB6; NbExp=3; IntAct=EBI-742054, EBI-10182490;
CC Q96D03; Q9Y3B2: EXOSC1; NbExp=3; IntAct=EBI-742054, EBI-371892;
CC Q96D03; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-742054, EBI-371876;
CC Q96D03; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-742054, EBI-371922;
CC Q96D03; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-742054, EBI-12013806;
CC Q96D03; Q13158: FADD; NbExp=3; IntAct=EBI-742054, EBI-494804;
CC Q96D03; P49789: FHIT; NbExp=3; IntAct=EBI-742054, EBI-741760;
CC Q96D03; Q14192: FHL2; NbExp=3; IntAct=EBI-742054, EBI-701903;
CC Q96D03; O75344: FKBP6; NbExp=3; IntAct=EBI-742054, EBI-744771;
CC Q96D03; P21333-2: FLNA; NbExp=5; IntAct=EBI-742054, EBI-9641086;
CC Q96D03; O95257: GADD45G; NbExp=3; IntAct=EBI-742054, EBI-448202;
CC Q96D03; Q8WXD5: GEMIN6; NbExp=3; IntAct=EBI-742054, EBI-752301;
CC Q96D03; O43681: GET3; NbExp=3; IntAct=EBI-742054, EBI-2515857;
CC Q96D03; Q92917: GPKOW; NbExp=3; IntAct=EBI-742054, EBI-746309;
CC Q96D03; P62993: GRB2; NbExp=3; IntAct=EBI-742054, EBI-401755;
CC Q96D03; Q6ZYL4: GTF2H5; NbExp=3; IntAct=EBI-742054, EBI-6380438;
CC Q96D03; Q969Y2: GTPBP3; NbExp=5; IntAct=EBI-742054, EBI-740290;
CC Q96D03; P43080: GUCA1A; NbExp=3; IntAct=EBI-742054, EBI-6873005;
CC Q96D03; Q8WUI4-6: HDAC7; NbExp=3; IntAct=EBI-742054, EBI-12094670;
CC Q96D03; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-742054, EBI-740641;
CC Q96D03; Q9UBY9: HSPB7; NbExp=5; IntAct=EBI-742054, EBI-739361;
CC Q96D03; Q9UBH0: IL36RN; NbExp=3; IntAct=EBI-742054, EBI-465156;
CC Q96D03; P20839-3: IMPDH1; NbExp=3; IntAct=EBI-742054, EBI-12188657;
CC Q96D03; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-742054, EBI-2556193;
CC Q96D03; Q7L273: KCTD9; NbExp=3; IntAct=EBI-742054, EBI-4397613;
CC Q96D03; Q8N371-3: KDM8; NbExp=3; IntAct=EBI-742054, EBI-12161375;
CC Q96D03; O76011: KRT34; NbExp=3; IntAct=EBI-742054, EBI-1047093;
CC Q96D03; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-742054, EBI-10250562;
CC Q96D03; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-742054, EBI-726510;
CC Q96D03; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-742054, EBI-10274069;
CC Q96D03; P47929: LGALS7B; NbExp=3; IntAct=EBI-742054, EBI-357504;
CC Q96D03; Q3ZCW2: LGALSL; NbExp=3; IntAct=EBI-742054, EBI-10241423;
CC Q96D03; P25800: LMO1; NbExp=3; IntAct=EBI-742054, EBI-8639312;
CC Q96D03; Q96KN1: LRATD2; NbExp=3; IntAct=EBI-742054, EBI-9057780;
CC Q96D03; P62310: LSM3; NbExp=3; IntAct=EBI-742054, EBI-348239;
CC Q96D03; Q9Y4Y9: LSM5; NbExp=3; IntAct=EBI-742054, EBI-373007;
CC Q96D03; Q9UK45: LSM7; NbExp=10; IntAct=EBI-742054, EBI-348372;
CC Q96D03; O15479: MAGEB2; NbExp=3; IntAct=EBI-742054, EBI-1057615;
CC Q96D03; P57077-4: MAP3K7CL; NbExp=3; IntAct=EBI-742054, EBI-10215880;
CC Q96D03; Q15555: MAPRE2; NbExp=3; IntAct=EBI-742054, EBI-739717;
CC Q96D03; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-742054, EBI-726739;
CC Q96D03; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-742054, EBI-1104564;
CC Q96D03; Q9BRT3: MIEN1; NbExp=3; IntAct=EBI-742054, EBI-6137472;
CC Q96D03; Q13064: MKRN3; NbExp=3; IntAct=EBI-742054, EBI-2340269;
CC Q96D03; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-742054, EBI-8852072;
CC Q96D03; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-742054, EBI-10288852;
CC Q96D03; Q15014: MORF4L2; NbExp=6; IntAct=EBI-742054, EBI-399257;
CC Q96D03; Q8N339: MT1M; NbExp=3; IntAct=EBI-742054, EBI-3911571;
CC Q96D03; Q969H8: MYDGF; NbExp=3; IntAct=EBI-742054, EBI-718622;
CC Q96D03; Q9HB07: MYG1; NbExp=3; IntAct=EBI-742054, EBI-709754;
CC Q96D03; P60660: MYL6; NbExp=3; IntAct=EBI-742054, EBI-300817;
CC Q96D03; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-742054, EBI-6952711;
CC Q96D03; P41227: NAA10; NbExp=4; IntAct=EBI-742054, EBI-747693;
CC Q96D03; Q8NEY1-3: NAV1; NbExp=5; IntAct=EBI-742054, EBI-11953718;
CC Q96D03; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-742054, EBI-928842;
CC Q96D03; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-742054, EBI-11978907;
CC Q96D03; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-742054, EBI-11750983;
CC Q96D03; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-742054, EBI-1055945;
CC Q96D03; Q9NPG2: NGB; NbExp=3; IntAct=EBI-742054, EBI-10311409;
CC Q96D03; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-742054, EBI-12868744;
CC Q96D03; Q9BZQ8: NIBAN1; NbExp=3; IntAct=EBI-742054, EBI-6916466;
CC Q96D03; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-742054, EBI-744782;
CC Q96D03; P16083: NQO2; NbExp=3; IntAct=EBI-742054, EBI-358466;
CC Q96D03; Q86WQ0: NR2C2AP; NbExp=3; IntAct=EBI-742054, EBI-10260040;
CC Q96D03; Q96G61: NUDT11; NbExp=3; IntAct=EBI-742054, EBI-1043825;
CC Q96D03; P50583: NUDT2; NbExp=3; IntAct=EBI-742054, EBI-10096247;
CC Q96D03; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-742054, EBI-10297093;
CC Q96D03; O95989: NUDT3; NbExp=3; IntAct=EBI-742054, EBI-713708;
CC Q96D03; Q9NPJ8-3: NXT2; NbExp=4; IntAct=EBI-742054, EBI-10698339;
CC Q96D03; P07237: P4HB; NbExp=3; IntAct=EBI-742054, EBI-395883;
CC Q96D03; Q6TGC4: PADI6; NbExp=3; IntAct=EBI-742054, EBI-10892722;
CC Q96D03; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-742054, EBI-3921217;
CC Q96D03; Q96KB5: PBK; NbExp=3; IntAct=EBI-742054, EBI-536853;
CC Q96D03; P57721-2: PCBP3; NbExp=3; IntAct=EBI-742054, EBI-11983983;
CC Q96D03; Q08493-2: PDE4C; NbExp=3; IntAct=EBI-742054, EBI-12169289;
CC Q96D03; P16118: PFKFB1; NbExp=3; IntAct=EBI-742054, EBI-709807;
CC Q96D03; Q99697-2: PITX2; NbExp=3; IntAct=EBI-742054, EBI-12138495;
CC Q96D03; Q9Y263: PLAA; NbExp=3; IntAct=EBI-742054, EBI-1994037;
CC Q96D03; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-742054, EBI-769257;
CC Q96D03; Q8IYS1: PM20D2; NbExp=3; IntAct=EBI-742054, EBI-11339910;
CC Q96D03; Q15126: PMVK; NbExp=3; IntAct=EBI-742054, EBI-1055562;
CC Q96D03; P28069: POU1F1; NbExp=3; IntAct=EBI-742054, EBI-8673859;
CC Q96D03; Q96CD2: PPCDC; NbExp=3; IntAct=EBI-742054, EBI-724333;
CC Q96D03; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-742054, EBI-2557649;
CC Q96D03; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-742054, EBI-5235602;
CC Q96D03; O43741: PRKAB2; NbExp=3; IntAct=EBI-742054, EBI-1053424;
CC Q96D03; Q99633: PRPF18; NbExp=3; IntAct=EBI-742054, EBI-2798416;
CC Q96D03; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-742054, EBI-5280197;
CC Q96D03; P60891: PRPS1; NbExp=3; IntAct=EBI-742054, EBI-749195;
CC Q96D03; P25786: PSMA1; NbExp=3; IntAct=EBI-742054, EBI-359352;
CC Q96D03; P28065: PSMB9; NbExp=3; IntAct=EBI-742054, EBI-603300;
CC Q96D03; Q03393: PTS; NbExp=3; IntAct=EBI-742054, EBI-712344;
CC Q96D03; Q9UHX1-2: PUF60; NbExp=3; IntAct=EBI-742054, EBI-11529177;
CC Q96D03; Q13637: RAB32; NbExp=3; IntAct=EBI-742054, EBI-9837586;
CC Q96D03; P40937: RFC5; NbExp=5; IntAct=EBI-742054, EBI-712376;
CC Q96D03; O75679: RFPL3; NbExp=3; IntAct=EBI-742054, EBI-10188956;
CC Q96D03; O76064: RNF8; NbExp=3; IntAct=EBI-742054, EBI-373337;
CC Q96D03; P49247: RPIA; NbExp=3; IntAct=EBI-742054, EBI-744831;
CC Q96D03; P35268: RPL22; NbExp=3; IntAct=EBI-742054, EBI-354533;
CC Q96D03; Q9NQG5: RPRD1B; NbExp=3; IntAct=EBI-742054, EBI-747925;
CC Q96D03; Q9UIL1-3: SCOC; NbExp=3; IntAct=EBI-742054, EBI-10692913;
CC Q96D03; Q12765-2: SCRN1; NbExp=3; IntAct=EBI-742054, EBI-12027936;
CC Q96D03; P55735-3: SEC13; NbExp=3; IntAct=EBI-742054, EBI-12235008;
CC Q96D03; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-742054, EBI-8652744;
CC Q96D03; Q8WYJ6: SEPTIN1; NbExp=3; IntAct=EBI-742054, EBI-693002;
CC Q96D03; Q9UH03: SEPTIN3; NbExp=3; IntAct=EBI-742054, EBI-727037;
CC Q96D03; Q99719: SEPTIN5; NbExp=3; IntAct=EBI-742054, EBI-373345;
CC Q96D03; O60880: SH2D1A; NbExp=3; IntAct=EBI-742054, EBI-6983382;
CC Q96D03; O14796: SH2D1B; NbExp=3; IntAct=EBI-742054, EBI-3923013;
CC Q96D03; Q9H299: SH3BGRL3; NbExp=3; IntAct=EBI-742054, EBI-5234893;
CC Q96D03; P09012: SNRPA; NbExp=3; IntAct=EBI-742054, EBI-607085;
CC Q96D03; P62308: SNRPG; NbExp=13; IntAct=EBI-742054, EBI-624585;
CC Q96D03; Q92673: SORL1; NbExp=3; IntAct=EBI-742054, EBI-1171329;
CC Q96D03; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-742054, EBI-10268630;
CC Q96D03; Q96MF2: STAC3; NbExp=3; IntAct=EBI-742054, EBI-745680;
CC Q96D03; O75716: STK16; NbExp=3; IntAct=EBI-742054, EBI-749295;
CC Q96D03; Q13043-2: STK4; NbExp=3; IntAct=EBI-742054, EBI-14280485;
CC Q96D03; O00204: SULT2B1; NbExp=3; IntAct=EBI-742054, EBI-749441;
CC Q96D03; P51687: SUOX; NbExp=3; IntAct=EBI-742054, EBI-3921347;
CC Q96D03; Q9BW92: TARS2; NbExp=3; IntAct=EBI-742054, EBI-1045099;
CC Q96D03; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-742054, EBI-8787464;
CC Q96D03; Q9Y242: TCF19; NbExp=3; IntAct=EBI-742054, EBI-7413767;
CC Q96D03; P56279: TCL1A; NbExp=3; IntAct=EBI-742054, EBI-749995;
CC Q96D03; Q9NUJ3: TCP11L1; NbExp=3; IntAct=EBI-742054, EBI-2555179;
CC Q96D03; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-742054, EBI-750487;
CC Q96D03; Q8IWB6: TEX14; NbExp=3; IntAct=EBI-742054, EBI-6674697;
CC Q96D03; A0A024R4Q5: TFPT; NbExp=4; IntAct=EBI-742054, EBI-11527449;
CC Q96D03; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-742054, EBI-74615;
CC Q96D03; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-742054, EBI-11525489;
CC Q96D03; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-742054, EBI-10259086;
CC Q96D03; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-742054, EBI-372432;
CC Q96D03; Q96PN8: TSSK3; NbExp=4; IntAct=EBI-742054, EBI-3918381;
CC Q96D03; Q8N0Z6: TTC5; NbExp=3; IntAct=EBI-742054, EBI-9526213;
CC Q96D03; P10599: TXN; NbExp=5; IntAct=EBI-742054, EBI-594644;
CC Q96D03; P83876: TXNL4A; NbExp=3; IntAct=EBI-742054, EBI-746539;
CC Q96D03; Q6IPR3: TYW3; NbExp=3; IntAct=EBI-742054, EBI-10974426;
CC Q96D03; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-742054, EBI-7353612;
CC Q96D03; P63146: UBE2B; NbExp=3; IntAct=EBI-742054, EBI-712629;
CC Q96D03; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-742054, EBI-17208936;
CC Q96D03; P61758: VBP1; NbExp=3; IntAct=EBI-742054, EBI-357430;
CC Q96D03; Q3SXR9: VCX2; NbExp=3; IntAct=EBI-742054, EBI-11983741;
CC Q96D03; Q14119: VEZF1; NbExp=3; IntAct=EBI-742054, EBI-11980193;
CC Q96D03; Q9P202: WHRN; NbExp=3; IntAct=EBI-742054, EBI-310886;
CC Q96D03; Q9NQW7-3: XPNPEP1; NbExp=3; IntAct=EBI-742054, EBI-12079490;
CC Q96D03; P07947: YES1; NbExp=3; IntAct=EBI-742054, EBI-515331;
CC Q96D03; Q5VVQ6: YOD1; NbExp=3; IntAct=EBI-742054, EBI-2510804;
CC Q96D03; P62699: YPEL5; NbExp=3; IntAct=EBI-742054, EBI-11721624;
CC Q96D03; Q8IZ13: ZBED8; NbExp=3; IntAct=EBI-742054, EBI-7186123;
CC Q96D03; Q15915: ZIC1; NbExp=3; IntAct=EBI-742054, EBI-11963196;
CC Q96D03; Q86VK4-3: ZNF410; NbExp=5; IntAct=EBI-742054, EBI-11741890;
CC Q96D03; O00488: ZNF593; NbExp=3; IntAct=EBI-742054, EBI-726769;
CC Q96D03; P36508: ZNF76; NbExp=3; IntAct=EBI-742054, EBI-7254550;
CC Q96D03; Q7L2R6-2: ZNF765; NbExp=3; IntAct=EBI-742054, EBI-12834294;
CC Q96D03; Q3MJ62: ZSCAN23; NbExp=3; IntAct=EBI-742054, EBI-5667532;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Up-regulated in atherosclerotic plaques relative to
CC healthy segments of the same artery. {ECO:0000269|PubMed:15308555}.
CC -!- INDUCTION: Up-regulated by oxidized LDL and hypoxia in macrophages.
CC {ECO:0000269|PubMed:15308555}.
CC -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR EMBL; AK094236; BAC04315.1; -; mRNA.
DR EMBL; AK312926; BAG35770.1; -; mRNA.
DR EMBL; AL832277; CAI46176.1; -; mRNA.
DR EMBL; CH471057; EAX06119.1; -; Genomic_DNA.
DR EMBL; BC013592; AAH13592.1; -; mRNA.
DR CCDS; CCDS34036.1; -.
DR RefSeq; NP_660287.1; NM_145244.3.
DR AlphaFoldDB; Q96D03; -.
DR SMR; Q96D03; -.
DR BioGRID; 125421; 162.
DR IntAct; Q96D03; 212.
DR STRING; 9606.ENSP00000354830; -.
DR MoonDB; Q96D03; Predicted.
DR iPTMnet; Q96D03; -.
DR PhosphoSitePlus; Q96D03; -.
DR BioMuta; DDIT4L; -.
DR DMDM; 74731396; -.
DR PaxDb; Q96D03; -.
DR PeptideAtlas; Q96D03; -.
DR PRIDE; Q96D03; -.
DR ProteomicsDB; 76241; -.
DR Antibodypedia; 25978; 254 antibodies from 23 providers.
DR DNASU; 115265; -.
DR Ensembl; ENST00000273990.6; ENSP00000354830.2; ENSG00000145358.6.
DR GeneID; 115265; -.
DR KEGG; hsa:115265; -.
DR MANE-Select; ENST00000273990.6; ENSP00000354830.2; NM_145244.4; NP_660287.1.
DR UCSC; uc003hvq.4; human.
DR CTD; 115265; -.
DR DisGeNET; 115265; -.
DR GeneCards; DDIT4L; -.
DR HGNC; HGNC:30555; DDIT4L.
DR HPA; ENSG00000145358; Group enriched (skeletal muscle, tongue).
DR MIM; 607730; gene.
DR neXtProt; NX_Q96D03; -.
DR OpenTargets; ENSG00000145358; -.
DR PharmGKB; PA128394749; -.
DR VEuPathDB; HostDB:ENSG00000145358; -.
DR eggNOG; ENOG502R3EE; Eukaryota.
DR GeneTree; ENSGT00530000063652; -.
DR InParanoid; Q96D03; -.
DR OMA; FAPTFRH; -.
DR OrthoDB; 1588396at2759; -.
DR PhylomeDB; Q96D03; -.
DR TreeFam; TF105007; -.
DR PathwayCommons; Q96D03; -.
DR SignaLink; Q96D03; -.
DR BioGRID-ORCS; 115265; 13 hits in 1060 CRISPR screens.
DR GenomeRNAi; 115265; -.
DR Pharos; Q96D03; Tbio.
DR PRO; PR:Q96D03; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96D03; protein.
DR Bgee; ENSG00000145358; Expressed in deltoid and 147 other tissues.
DR ExpressionAtlas; Q96D03; baseline and differential.
DR Genevisible; Q96D03; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
DR Gene3D; 3.90.470.40; -; 1.
DR InterPro; IPR012918; RTP801-like.
DR InterPro; IPR038281; RTP801-like_C_sf.
DR PANTHER; PTHR12478; PTHR12478; 1.
DR Pfam; PF07809; RTP801_C; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..193
FT /note="DNA damage-inducible transcript 4-like protein"
FT /id="PRO_0000307204"
FT VARIANT 161
FT /note="S -> F (in dbSNP:rs11553154)"
FT /id="VAR_053971"
SQ SEQUENCE 193 AA; 21740 MW; 3BEEB3D0530C5BFF CRC64;
MVATGSLSSK NPASISELLD CGYHPESLLS DFDYWDYVVP EPNLNEVIFE ESTCQNLVKM
LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK
LDRIVCDSSV VPTFELTLVF KQENCSWTSF RDFFFSRGRF SSGFRRTLIL SSGFRLVKKK
LYSLIGTTVI EGS
