DDT4L_MOUSE
ID DDT4L_MOUSE Reviewed; 193 AA.
AC Q8VHZ5; Q8C0Z7; Q8VD49; Q9CQV2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=DNA damage-inducible transcript 4-like protein;
DE AltName: Full=HIF-1 responsive protein RTP801-like;
DE AltName: Full=Soleus muscle atrophied after hindlimb suspension protein 1;
GN Name=Ddit4l; Synonyms=Rtp801l, Smhs1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/10ScNJ; TISSUE=Skeletal muscle;
RX PubMed=11596118; DOI=10.1002/jcb.1248;
RA Cros N., Tkatchenko A.V., Pisani D.F., Leclerc L., Leger J.J.,
RA Marini J.-F., Dechesne C.A.;
RT "Analysis of altered gene expression in rat soleus muscle atrophied by
RT disuse.";
RL J. Cell. Biochem. 83:508-519(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11884613; DOI=10.1128/mcb.22.7.2283-2293.2002;
RA Shoshani T., Faerman A., Mett I., Zelin E., Tenne T., Gorodin S.,
RA Moshel Y., Elbaz S., Budanov A., Chajut A., Kalinski H., Kamer I.,
RA Rozen A., Mor O., Keshet E., Leshkowitz D., Einat P., Skaliter R.,
RA Feinstein E.;
RT "Identification of a novel hypoxia-inducible factor 1-responsive gene,
RT RTP801, involved in apoptosis.";
RL Mol. Cell. Biol. 22:2283-2293(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, Head, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits cell growth by regulating the TOR signaling pathway
CC upstream of the TSC1-TSC2 complex and downstream of AKT1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR EMBL; AF327512; AAL39013.1; -; mRNA.
DR EMBL; AF335325; AAL38425.1; -; mRNA.
DR EMBL; AK006617; BAB24676.1; -; mRNA.
DR EMBL; AK018944; BAB31490.1; -; mRNA.
DR EMBL; AK029362; BAC26417.1; -; mRNA.
DR EMBL; AK053333; BAC35350.1; -; mRNA.
DR EMBL; BC038131; AAH38131.1; -; mRNA.
DR CCDS; CCDS17863.1; -.
DR RefSeq; NP_084419.2; NM_030143.4.
DR AlphaFoldDB; Q8VHZ5; -.
DR SMR; Q8VHZ5; -.
DR BioGRID; 215892; 1.
DR IntAct; Q8VHZ5; 2.
DR MINT; Q8VHZ5; -.
DR STRING; 10090.ENSMUSP00000058896; -.
DR iPTMnet; Q8VHZ5; -.
DR PhosphoSitePlus; Q8VHZ5; -.
DR PaxDb; Q8VHZ5; -.
DR PRIDE; Q8VHZ5; -.
DR ProteomicsDB; 279321; -.
DR Antibodypedia; 25978; 254 antibodies from 23 providers.
DR DNASU; 73284; -.
DR Ensembl; ENSMUST00000053855; ENSMUSP00000058896; ENSMUSG00000046818.
DR GeneID; 73284; -.
DR KEGG; mmu:73284; -.
DR UCSC; uc008rmn.2; mouse.
DR CTD; 115265; -.
DR MGI; MGI:1920534; Ddit4l.
DR VEuPathDB; HostDB:ENSMUSG00000046818; -.
DR eggNOG; ENOG502R3EE; Eukaryota.
DR GeneTree; ENSGT00530000063652; -.
DR HOGENOM; CLU_086145_0_0_1; -.
DR InParanoid; Q8VHZ5; -.
DR OMA; FAPTFRH; -.
DR OrthoDB; 1588396at2759; -.
DR PhylomeDB; Q8VHZ5; -.
DR TreeFam; TF105007; -.
DR BioGRID-ORCS; 73284; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ddit4l; mouse.
DR PRO; PR:Q8VHZ5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8VHZ5; protein.
DR Bgee; ENSMUSG00000046818; Expressed in temporalis muscle and 209 other tissues.
DR ExpressionAtlas; Q8VHZ5; baseline and differential.
DR Genevisible; Q8VHZ5; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
DR Gene3D; 3.90.470.40; -; 1.
DR InterPro; IPR012918; RTP801-like.
DR InterPro; IPR038281; RTP801-like_C_sf.
DR PANTHER; PTHR12478; PTHR12478; 1.
DR Pfam; PF07809; RTP801_C; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..193
FT /note="DNA damage-inducible transcript 4-like protein"
FT /id="PRO_0000307205"
FT CONFLICT 28
FT /note="L -> M (in Ref. 1; AAL39013)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="F -> Y (in Ref. 3; BAB24676/BAB31490)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 193 AA; 21581 MW; 53648D6100CE5B0D CRC64;
MVATGSLSSK NPASISELLD GGYHPGSLLS DFDYWDYVVP EPNLNEVVFE ETTCQNLVKM
LENCLSRSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK
LDRIVCDASV VPTFELTLVF KQESCPWTSL KDFFFSRGRF SSGLKRTLIL SSGFRLVKKK
LYSLIGTTVI EEC
