ID   DDT4L_ONCMY             Reviewed;         206 AA.
AC   Q20A00;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=DNA damage-inducible transcript 4-like protein;
GN   Name=ddit4l;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX   DOI=10.1016/j.cbd.2006.10.003;
RA   Iliev D.B., Goetz G.W., MacKenzie S., Planas J.V., Goetz F.W.;
RT   "Pathogen-associated gene expression profiles in rainbow trout
RT   macrophages.";
RL   Comp. Biochem. Physiol. 1D:416-422(2006).
CC   -!- FUNCTION: Inhibits cell growth by regulating the TOR signaling pathway
CC       upstream of the tsc1-tsc2 complex and downstream of akt1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Induced by LPS and zymosan in macrophages.
CC       {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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DR   EMBL; DQ400410; ABD64616.1; -; mRNA.
DR   RefSeq; NP_001118047.1; NM_001124575.1.
DR   AlphaFoldDB; Q20A00; -.
DR   SMR; Q20A00; -.
DR   Ensembl; ENSOMYT00000025577; ENSOMYP00000023338; ENSOMYG00000011149.
DR   GeneID; 100136335; -.
DR   KEGG; omy:100136335; -.
DR   GeneTree; ENSGT00530000063652; -.
DR   OrthoDB; 1588396at2759; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 3.90.470.40; -; 1.
DR   InterPro; IPR012918; RTP801-like.
DR   InterPro; IPR038281; RTP801-like_C_sf.
DR   PANTHER; PTHR12478; PTHR12478; 1.
DR   Pfam; PF07809; RTP801_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm.
FT   CHAIN           1..206
FT                   /note="DNA damage-inducible transcript 4-like protein"
FT                   /id="PRO_0000307208"
SQ   SEQUENCE   206 AA;  23298 MW;  8E720291AF2041C0 CRC64;
     MVYTPALVLG HGIPIVSEED NIVELMRKFL CQITSSDNKY VRRGSIESSE FIKEINSSLD
     SETAPDCEER ILHQDMTRQI VRCLSEAKES SLRCRILLLP RTLTANVALD VVRSSAGEPC
     GLRGAFIQVY LETQLGQQLQ MLGTITPDPT VTPTFELSVV FKLDKDCWPL LKHIFVTDKV
     LKLRPQYRLV KKKLYSSASP VIHEFC