ID   DDT4L_RAT               Reviewed;         193 AA.
AC   Q8VD50;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA damage-inducible transcript 4-like protein;
DE   AltName: Full=Soleus muscle atrophied after hindlimb suspension protein 1;
GN   Name=Ddit4l; Synonyms=Smhs1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
RX   PubMed=11596118; DOI=10.1002/jcb.1248;
RA   Cros N., Tkatchenko A.V., Pisani D.F., Leclerc L., Leger J.J.,
RA   Marini J.-F., Dechesne C.A.;
RT   "Analysis of altered gene expression in rat soleus muscle atrophied by
RT   disuse.";
RL   J. Cell. Biochem. 83:508-519(2001).
CC   -!- FUNCTION: Inhibits cell growth by regulating the TOR signaling pathway
CC       upstream of the TSC1-TSC2 complex and downstream of AKT1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle and testis.
CC       {ECO:0000269|PubMed:11596118}.
CC   -!- INDUCTION: Up-regulated in soleus muscle atrophied by disuse.
CC       {ECO:0000269|PubMed:11596118}.
CC   -!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF327511; AAL39012.1; -; mRNA.
DR   RefSeq; NP_536324.1; NM_080399.1.
DR   RefSeq; XP_002729167.1; XM_002729121.5.
DR   RefSeq; XP_003753712.1; XM_003753664.4.
DR   AlphaFoldDB; Q8VD50; -.
DR   SMR; Q8VD50; -.
DR   STRING; 10116.ENSRNOP00000013661; -.
DR   PhosphoSitePlus; Q8VD50; -.
DR   PaxDb; Q8VD50; -.
DR   Ensembl; ENSRNOT00000013661; ENSRNOP00000013661; ENSRNOG00000010047.
DR   GeneID; 100363484; -.
DR   GeneID; 140582; -.
DR   KEGG; rno:140582; -.
DR   CTD; 115265; -.
DR   CTD; 140582; -.
DR   RGD; 619738; Ddit4l.
DR   eggNOG; ENOG502R3EE; Eukaryota.
DR   GeneTree; ENSGT00530000063652; -.
DR   HOGENOM; CLU_086145_0_0_1; -.
DR   InParanoid; Q8VD50; -.
DR   OMA; FAPTFRH; -.
DR   OrthoDB; 1588396at2759; -.
DR   PhylomeDB; Q8VD50; -.
DR   TreeFam; TF105007; -.
DR   PRO; PR:Q8VD50; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000010047; Expressed in esophagus and 15 other tissues.
DR   Genevisible; Q8VD50; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 3.90.470.40; -; 1.
DR   InterPro; IPR012918; RTP801-like.
DR   InterPro; IPR038281; RTP801-like_C_sf.
DR   PANTHER; PTHR12478; PTHR12478; 1.
DR   Pfam; PF07809; RTP801_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..193
FT                   /note="DNA damage-inducible transcript 4-like protein"
FT                   /id="PRO_0000307207"
SQ   SEQUENCE   193 AA;  21400 MW;  344095D9B1CBDEA2 CRC64;
     MVATGSLSSK NTASISELLD GGSHPGSLLS DFDYWDYVVP EPNLNEVVFE ETTCQNLVKM
     LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK
     LDRIVCDASV VPTFELTLVF KQESCSWTSL KDFFFSGGRF SSGLRRTLIL SSGFRLVKKK
     LYSLIGTTVI EEC