ID   DDTL_HUMAN              Reviewed;         134 AA.
AC   A6NHG4; B4DJJ7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=D-dopachrome decarboxylase-like protein;
DE            EC=4.1.1.-;
DE   AltName: Full=D-dopachrome tautomerase-like protein;
GN   Name=DDTL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
CC   -!- FUNCTION: May have lyase activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000305}.
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DR   EMBL; AK296110; BAG58859.1; -; mRNA.
DR   EMBL; DC339950; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AP000350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS42988.1; -.
DR   RefSeq; NP_001077862.1; NM_001084393.1.
DR   AlphaFoldDB; A6NHG4; -.
DR   SMR; A6NHG4; -.
DR   BioGRID; 755774; 13.
DR   IntAct; A6NHG4; 1.
DR   MINT; A6NHG4; -.
DR   STRING; 9606.ENSP00000215770; -.
DR   iPTMnet; A6NHG4; -.
DR   PhosphoSitePlus; A6NHG4; -.
DR   BioMuta; DDTL; -.
DR   jPOST; A6NHG4; -.
DR   MassIVE; A6NHG4; -.
DR   MaxQB; A6NHG4; -.
DR   PaxDb; A6NHG4; -.
DR   PeptideAtlas; A6NHG4; -.
DR   PRIDE; A6NHG4; -.
DR   ProteomicsDB; 1195; -.
DR   DNASU; 100037417; -.
DR   Ensembl; ENST00000215770.6; ENSP00000215770.5; ENSG00000099974.8.
DR   Ensembl; ENST00000621454.2; ENSP00000479063.1; ENSG00000275758.2.
DR   GeneID; 100037417; -.
DR   KEGG; hsa:100037417; -.
DR   MANE-Select; ENST00000215770.6; ENSP00000215770.5; NM_001084393.2; NP_001077862.1.
DR   UCSC; uc002zyy.5; human.
DR   CTD; 100037417; -.
DR   DisGeNET; 100037417; -.
DR   GeneCards; DDTL; -.
DR   HGNC; HGNC:33446; DDTL.
DR   HPA; ENSG00000099974; Tissue enhanced (liver).
DR   neXtProt; NX_A6NHG4; -.
DR   OpenTargets; ENSG00000099974; -.
DR   PharmGKB; PA162383433; -.
DR   VEuPathDB; HostDB:ENSG00000099974; -.
DR   eggNOG; KOG1759; Eukaryota.
DR   GeneTree; ENSGT00940000156821; -.
DR   HOGENOM; CLU_129906_2_1_1; -.
DR   InParanoid; A6NHG4; -.
DR   OMA; TEGAKSC; -.
DR   OrthoDB; 1515400at2759; -.
DR   PhylomeDB; A6NHG4; -.
DR   TreeFam; TF313853; -.
DR   PathwayCommons; A6NHG4; -.
DR   SignaLink; A6NHG4; -.
DR   BioGRID-ORCS; 100037417; 77 hits in 1007 CRISPR screens.
DR   ChiTaRS; DDTL; human.
DR   GenomeRNAi; 100037417; -.
DR   Pharos; A6NHG4; Tdark.
DR   PRO; PR:A6NHG4; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; A6NHG4; protein.
DR   Bgee; ENSG00000099974; Expressed in right lobe of liver and 96 other tissues.
DR   ExpressionAtlas; A6NHG4; baseline and differential.
DR   Genevisible; A6NHG4; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0050178; F:phenylpyruvate tautomerase activity; IBA:GO_Central.
DR   Gene3D; 3.30.429.10; -; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; PTHR11954; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; SSF55331; 1.
DR   PROSITE; PS01158; MIF; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Lyase; Reference proteome.
FT   CHAIN           1..134
FT                   /note="D-dopachrome decarboxylase-like protein"
FT                   /id="PRO_0000337242"
SQ   SEQUENCE   134 AA;  14195 MW;  B524E7EF14C1A555 CRC64;
     MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL
     SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRFPTVL STSPAAHGGP RCPGEIIEGK
     KSCLNEEALF IYFI