ID   DDX17_TRYBB             Reviewed;         568 AA.
AC   Q26696;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Putative DEAD-box RNA helicase HEL64;
DE            EC=3.6.4.13;
GN   Name=HEL64;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IsTar I.7;
RX   PubMed=8720182; DOI=10.1016/0166-6851(95)02511-1;
RA   Missel A., Norskau G., Shu H.H., Goringer H.U.;
RT   "A putative RNA helicase of the DEAD box family from Trypanosoma brucei.";
RL   Mol. Biochem. Parasitol. 75:123-126(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U29199; AAC46964.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q26696; -.
DR   SMR; Q26696; -.
DR   PRIDE; Q26696; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR   GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR   GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR   GO; GO:0005524; F:ATP binding; ISM:GeneDB.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; ISM:GeneDB.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; RNA-binding.
FT   CHAIN           1..568
FT                   /note="Putative DEAD-box RNA helicase HEL64"
FT                   /id="PRO_0000055047"
FT   DOMAIN          133..307
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          335..483
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           102..130
FT                   /note="Q motif"
FT   MOTIF           255..258
FT                   /note="DEAD box"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         146..153
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   568 AA;  64157 MW;  B4D5E426C7F93868 CRC64;
     MEETYSPFTG RQGQYNQGYN GGGRRDSRGG MGERIKPVDW GNVSLVPGNW KVLDGKAIKK
     AGEIKTSTPE AGQLSEEEAT KWREEHVITI FGDDCPPPMS SFDHLCGIVP PYLLKKLTAQ
     NFTAPTPVQA QSWPVLLSGR DLVGVAKTGS GKTLGFMVPA LAHIAVQEPL RSGDGPMVVV
     LAPTRELAQQ IEEETKKVIP GDVYCGCVYG GAPKGPQLGL LRRGVHILVA TPGRLIDFLD
     IKRINLHRVT YLVLDEADRM LDMGFEPQVR KICGQIRPDR QTVMFSATWP REIQRLAAEF
     QKQWIRISVG STELQANKDV TQRFILTQEF AKQDELRKLM QEHREERVLV FCKMKRTADE
     LERQLRRWGY DAMAIHGDKE QRQREFILAR FRKDPRLCLV ATDVAARGLD IKQLETVINY
     DFPMQIDDYV HRIGRTGRAG GEGRCVYLIT KKEAQITPSV LKELIGILER AQQEIPDWMI
     EWNAQQPRYQ VKRNRGMNGF GRHQSAPFLR NGHRPSFSAN GNYSAHGNGT FGLGKHNDDA
     VPFSSSAIQY KRFDSDDEAE PSRKKYAR